Ethyl 4-{3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

Base Information

Chemical Name:Ethyl 4-{3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate
CAS No.:1204423-90-4
Molecular Formula:C₂₂H₂₄BrN₃O₅
Molecular Weight:490.354
Hs Code.:

Synonyms:Ethyl 4-{3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

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Chemical Property of Ethyl 4-{3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

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Technology Process of Ethyl 4-{3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

There total 12 articles about Ethyl 4-{3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₃H₁₂BrNO₄

: 4-amino-1-ethylpyrrole-3-carboxylic acid ethyl ester hydrochloride

: 1204423-90-4
Ethyl 4-{3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1204423-90-4
Ethyl 4-{3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 1 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Cooling with ice

3.1: triethylamine / dichloromethane / 2 h / 20 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice

5.1: potassium carbonate / acetonitrile / 20 °C

6.1: sodium hydroxide; water / tetrahydrofuran / 72 h / 20 °C

6.2: 6.5 h / 120 °C

7.1: tetrahydrofuran; methanol / 48 h / 20 °C

8.1: N-Bromosuccinimide; acetic acid / 4 h / 70 °C

9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

10.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; carbon tetrabromide; hydroxylamine hydrochloride; water; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9
p-methoxyl benzaldoxime

: 1204423-90-4
Ethyl 4-{3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propanoylamino}-1-ethylpyrrole-3-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice

4.1: potassium carbonate / acetonitrile / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran / 72 h / 20 °C

5.2: 6.5 h / 120 °C

6.1: tetrahydrofuran; methanol / 48 h / 20 °C

7.1: N-Bromosuccinimide; acetic acid / 4 h / 70 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With N-chloro-succinimide; N-Bromosuccinimide; carbon tetrabromide; water; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;