(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate

Base Information

Chemical Name:(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate
CAS No.:449779-80-0
Molecular Formula:C₁₈H₂₃NO₄
Molecular Weight:317.385
Hs Code.:

Synonyms:(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate

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Chemical Property of (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate

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Technology Process of (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate

There total 2 articles about (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 51208-83-4
2-(4-isopropylphenyl)-2-oxoacetic acid

: 151670-13-2
(D)-1-(1-pyrrolidinyl)-2-hydroxy-1-propanone

: 449779-80-0
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate

Guidance literature:: 2-(4-isopropylphenyl)-2-oxoacetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 0.5h; Heating;

(D)-1-(1-pyrrolidinyl)-2-hydroxy-1-propanone; With triethylamine; In dichloromethane; at 0 - 25 ℃; for 0.5h;
DOI:10.1021/jm0502135

Reference yield:

: 98-82-8
Isopropylbenzene

: 449779-80-0
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: AlCl₃ / CH₂Cl₂ / 2 h / 25 °C

1.2: aq. NaOH / methanol / 0.5 h

2.1: oxalyl chloride; DMF / CH₂Cl₂ / 0.5 h / Heating

2.2: 80 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 25 °C

With aluminium trichloride; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1021/jm0502135

Reference yield: 82.0%

: 449779-80-0
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate

: 449779-79-7
(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate

Guidance literature:: (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate; With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 0.5h;

With phosphorus tribromide; In dichloromethane; at 25 ℃; for 0.5h;
DOI:10.1021/jm0502135