α-(Trimethylsiloxy)-m-fluorstyrol

Base Information

• Chemical Name: α-(Trimethylsiloxy)-m-fluorstyrol
• CAS No.: 52186-49-9
• Molecular Formula: C₁₁H₁₅FOSi
• Molecular Weight: 210.323
• Mol file: 52186-49-9.mol

Synonyms:α-(Trimethylsiloxy)-m-fluorstyrol

Chemical Property of α-(Trimethylsiloxy)-m-fluorstyrol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-(Trimethylsiloxy)-m-fluorstyrol

There total 2 articles about α-(Trimethylsiloxy)-m-fluorstyrol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + 1-(3-fluorophenyl)ethanone (455-36-7) → α-(Trimethylsiloxy)-m-fluorstyrol (52186-49-9)

Guidance literature:

1-(3-fluorophenyl)ethanone; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 0.5h;

chloro-trimethyl-silane; In tetrahydrofuran;

DOI:10.1021/acs.orglett.7b03587

Reference yield:

1,1-dimethylsilacyclobutane (2295-12-7) + 1-(3-fluorophenyl)ethanone (455-36-7) → α-(Trimethylsiloxy)-m-fluorstyrol (52186-49-9)

Guidance literature:

at 611 ℃;

DOI:10.1016/S0022-328X(00)93884-1

Reference yield: 96.0%

N-methoxybenzamide (2446-51-7) + α-(Trimethylsiloxy)-m-fluorstyrol (52186-49-9) → C16H14FNO3

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate; In tetrahydrofuran; at 50 ℃; for 15h;

DOI:10.1021/acscatal.9b05622

upstream raw materials:

1,1-dimethylsilacyclobutane

1-(3-fluorophenyl)ethanone

chloro-trimethyl-silane

Downstream raw materials:

1-(3-fluorophenyl)-2-hydroxyethan-1-one

Refernces

• 1、 Chen, Yuehua,Deng, Hao,Gao, Xing,Guo, Hongchao,Jiang, Feng,Wang, Wei,Wu, Yongjun,Zhu, Dongyu. "Palladium-Catalyzed [5 + 2] Annulation of Vinylethylene Carbonates with Barbiturate-Derived Alkenes". supporting information. p. 7158 - 7163. Retrieved 2020/10/02.