Technology Process of C9H9Cl2FO3S
There total 6 articles about C9H9Cl2FO3S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(2,6-dichloro-3-fluorophenyl)ethyl acetate;
With
pig liver esterase; sodium hydroxide;
at 23 ℃;
for 30h;
aq. phosphate buffer;
Large scale reaction;
Enzymatic reaction;
methanesulfonyl chloride;
With
pyridine;
at 23 ℃;
for 3h;
enantioselective reaction;
Inert atmosphere;
DOI:10.1016/j.tetasy.2010.09.007
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
2: pyridine / dichloromethane / 12 h / 20 °C
3: sodium hydroxide / aq. phosphate buffer / 20 h / 20 °C / pH 7.0 / Enzymatic reaction
4: pyridine / 3 h / 20 °C / Inert atmosphere
With
pyridine; lithium aluminium tetrahydride; sodium hydroxide;
In
tetrahydrofuran; aq. phosphate buffer; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C
2.1: pyridine / dichloromethane / 12 h / 20 °C
3.1: sodium hydroxide / aq. phosphate buffer / 20 h / 20 °C / pH 7
3.2: 3 h / 20 °C / Inert atmosphere
With
pyridine; lithium aluminium tetrahydride; sodium hydroxide;
In
tetrahydrofuran; aq. phosphate buffer; dichloromethane;