4-[(3R)-3-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperiridin-1-yl]butyric acid methyl ester formate

Base Information

Chemical Name:4-[(3R)-3-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperiridin-1-yl]butyric acid methyl ester formate
CAS No.:1073135-60-0
Molecular Formula:CH₂O₂*C₂₉H₃₀FN₃O₅
Molecular Weight:565.598
Hs Code.:

Synonyms:4-[(3R)-3-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperiridin-1-yl]butyric acid methyl ester formate

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Chemical Property of 4-[(3R)-3-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperiridin-1-yl]butyric acid methyl ester formate

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Technology Process of 4-[(3R)-3-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperiridin-1-yl]butyric acid methyl ester formate

There total 8 articles about 4-[(3R)-3-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperiridin-1-yl]butyric acid methyl ester formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 64-18-6
formic acid

: 4897-84-1
Methyl 4-bromobutyrate

: 6-(2-fluorophenyl)-5-(4-methoxyphenyl)-4-[(3R)-piperidin-3-yloxy]furo[2,3-d]pyrimidine formate

: 1073135-60-0
4-[(3R)-3-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperiridin-1-yl]butyric acid methyl ester formate

Guidance literature:: Methyl 4-bromobutyrate; 6-(2-fluorophenyl)-5-(4-methoxyphenyl)-4-[(3R)-piperidin-3-yloxy]furo[2,3-d]pyrimidine formate; With formic acid; tetra-(n-butyl)ammonium iodide; potassium carbonate; In tetrahydrofuran; at 80 ℃; for 13h;

formic acid; In water; acetonitrile;

Reference yield:

: 66985-48-6
2-(4-methoxyphenyl)-2-(trimethylsilyloxy)acetonitrile

: 1073135-60-0
4-[(3R)-3-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperiridin-1-yl]butyric acid methyl ester formate

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisopropylamine; n-butyllithium / hexane; 1,2-dimethoxyethane / 1 h / -60 °C

1.2: 4.33 h / -60 - 20 °C

1.3: 16 h / 20 °C

2.1: triethylamine / tetrahydrofuran / 20 °C / Cooling with ice

3.1: acetic anhydride / 0 °C

3.2: 24 h / 130 °C

4.1: trichlorophosphate / sulfolane / 1 h / 120 °C

4.2: 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h

5.2: 16 h / Reflux

6.1: palladium / methanol / 48 h / 20 °C / Inert atmosphere

7.1: potassium carbonate; tetra-(n-butyl)ammonium iodide; formic acid / tetrahydrofuran / 13 h / 80 °C

With n-butyllithium; formic acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; triethylamine; diisopropylamine; trichlorophosphate; palladium; In tetrahydrofuran; sulfolane; methanol; 1,2-dimethoxyethane; hexane; mineral oil;

Reference yield:

: 1073136-37-4
4-chloro-6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidine

: 1073135-60-0
4-[(3R)-3-{[6-(2-fluorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}piperiridin-1-yl]butyric acid methyl ester formate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h

1.2: 16 h / Reflux

2.1: palladium / methanol / 48 h / 20 °C / Inert atmosphere

3.1: potassium carbonate; tetra-(n-butyl)ammonium iodide; formic acid / tetrahydrofuran / 13 h / 80 °C

With formic acid; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; palladium; In tetrahydrofuran; methanol; mineral oil;