1,1-Dimethylethyl*,R^*),4R>>-1-<α-methoxy-α-(trifluoromethyl)-α-phenylacetyl>-4-(4,4-dimethoxy-2-butynyl)-2,2-dimethyl-3-oxazolidinecarboxylate

Base Information

• Chemical Name: 1,1-Dimethylethyl*,R^*),4R>>-1-<α-methoxy-α-(trifluoromethyl)-α-phenylacetyl>-4-(4,4-dimethoxy-2-butynyl)-2,2-dimethyl-3-oxazolidinecarboxylate
• CAS No.: 127308-65-0
• Molecular Formula: C₂₆H₃₂F₃NO₈
• Molecular Weight: 543.537
• Mol file: 127308-65-0.mol

Synonyms:1,1-Dimethylethyl*,R^*),4R>>-1-<α-methoxy-α-(trifluoromethyl)-α-phenylacetyl>-4-(4,4-dimethoxy-2-butynyl)-2,2-dimethyl-3-oxazolidinecarboxylate

Chemical Property of 1,1-Dimethylethyl*,R^*),4R>>-1-<α-methoxy-α-(trifluoromethyl)-α-phenylacetyl>-4-(4,4-dimethoxy-2-butynyl)-2,2-dimethyl-3-oxazolidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-Dimethylethyl*,R^*),4R>>-1-<α-methoxy-α-(trifluoromethyl)-α-phenylacetyl>-4-(4,4-dimethoxy-2-butynyl)-2,2-dimethyl-3-oxazolidinecarboxylate

There total 3 articles about 1,1-Dimethylethyl*,R^*),4R>>-1-<α-methoxy-α-(trifluoromethyl)-α-phenylacetyl>-4-(4,4-dimethoxy-2-butynyl)-2,2-dimethyl-3-oxazolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid (20445-31-2) + 1,1-Dimethylethyl*,S*)>-4-(4-ethoxy-1-hydroxy-4-oxo-2-butynyl)-2,2-dimethyl-3-oxazolidinecarboxylate (127257-22-1) → 1,1-Dimethylethyl*,R*),4R>>-1-<α-methoxy-α-(trifluoromethyl)-α-phenylacetyl>-4-(4,4-dimethoxy-2-butynyl)-2,2-dimethyl-3-oxazolidinecarboxylate (127308-65-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 12h; Ambient temperature;

DOI:10.1021/jo00299a017

Reference yield:

(R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine (95715-87-0) → 1,1-Dimethylethyl*,R*),4R>>-1-<α-methoxy-α-(trifluoromethyl)-α-phenylacetyl>-4-(4,4-dimethoxy-2-butynyl)-2,2-dimethyl-3-oxazolidinecarboxylate (127308-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) n-BuLi, 2) HMPA / 1) -78 deg C, 1h, THF, 2) -78 deg C, 1h, THF

2: 87 percent / DCC,DMAP / CH₂Cl₂ / 12 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jo00299a017

Reference yield:

propynoic acid ethyl ester (623-47-2) → 1,1-Dimethylethyl*,R*),4R>>-1-<α-methoxy-α-(trifluoromethyl)-α-phenylacetyl>-4-(4,4-dimethoxy-2-butynyl)-2,2-dimethyl-3-oxazolidinecarboxylate (127308-65-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) n-BuLi, 2) HMPA / 1) -78 deg C, 1h, THF, 2) -78 deg C, 1h, THF

2: 87 percent / DCC,DMAP / CH₂Cl₂ / 12 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jo00299a017

upstream raw materials:

R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

1,1-Dimethylethyl*,S^*)>-4-(4-ethoxy-1-hydroxy-4-oxo-2-butynyl)-2,2-dimethyl-3-oxazolidinecarboxylate

(R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine

propynoic acid ethyl ester