6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine

Base Information

• Chemical Name: 6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine
• CAS No.: 1332875-23-6
• Molecular Formula: C₁₄H₁₂ClF₃N₂O
• Molecular Weight: 316.71
• Mol file: 1332875-23-6.mol

Synonyms:6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine

Chemical Property of 6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine

There total 1 articles about 6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.6%

2,6-dichloro-4-(trifluoromethyl)pyridine (39890-98-7) + 4-methoxy-benzylamine (2393-23-9) → 6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine (1332875-23-6)

Guidance literature:

at 110 ℃; for 18h;

Reference yield: 74.3%

zinc(II) cyanide (557-21-1) + 6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine (1332875-23-6) → 6-((4-methoxybenzyl)amine)-4-(trifluoromethyl)pyridin-2-cyanide

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl acetamide; at 95 ℃; for 16h; Inert atmosphere;

Reference yield:

6-chloro-N-(4-methoxybenzyl)-4-(trifluoromethyl)pyridin-2-amine (1332875-23-6) + 2-(trifluoromethyl)phenylboronic acid (1423-27-4) → (4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine (1332875-24-7)

Guidance literature:

With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 80 ℃; for 4h; Inert atmosphere;

upstream raw materials:

2,6-dichloro-4-(trifluoromethyl)pyridine

4-methoxy-benzylamine

Downstream raw materials:

(4-Methoxy-benzyl)-[4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amine

2-(3-tert-butyl-isoxazol-5-yl)-7-trifluoromethyl-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine

3-nitro-4-trifluoromethyl-6-(2-trifluoromethyl-phenyl)-pyridin-2-ylamine