5-tert-butyl-3-[(N,N-dimethylamino)methyl]-2-hydroxybenzaldehyde

Base Information

• Chemical Name: 5-tert-butyl-3-[(N,N-dimethylamino)methyl]-2-hydroxybenzaldehyde
• CAS No.: 478282-20-1
• Molecular Formula: C₁₄H₂₁NO₂
• Molecular Weight: 235.326
• Mol file: 478282-20-1.mol

Synonyms:5-tert-butyl-3-[(N,N-dimethylamino)methyl]-2-hydroxybenzaldehyde

Chemical Property of 5-tert-butyl-3-[(N,N-dimethylamino)methyl]-2-hydroxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-tert-butyl-3-[(N,N-dimethylamino)methyl]-2-hydroxybenzaldehyde

There total 2 articles about 5-tert-butyl-3-[(N,N-dimethylamino)methyl]-2-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-hydroxy-5-t-butylbenzaldehyde (2725-53-3) + dimethyl amine (124-40-3) → 5-tert-butyl-3-[(N,N-dimethylamino)methyl]-2-hydroxybenzaldehyde (478282-20-1)

Guidance literature:

In ethanol; for 24h; Heating;

DOI:10.1016/j.tet.2005.03.117

Reference yield:

para-tert-butylphenol (98-54-4) → 5-tert-butyl-3-[(N,N-dimethylamino)methyl]-2-hydroxybenzaldehyde (478282-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 85 percent / SnCl₄; Bu₃N / toluene; CH₂Cl₂ / 8 h / Heating

2.1: glacial acetic acid / 0.25 h / 20 °C

2.2: 54 percent / glacial acetic acid / 4 h / Heating

With tributyl-amine; tin(IV) chloride; acetic acid; In dichloromethane; toluene;

DOI:10.1021/ac051010r

Reference yield: 100.0%

5-tert-butyl-3-[(N,N-dimethylamino)methyl]-2-hydroxybenzaldehyde (478282-20-1) + (1R,2R)-1,2-diaminocyclohexane (20439-47-8) → C34H52N4O2

Guidance literature:

In ethanol; at 20 ℃; for 24h;

DOI:10.1021/ja026498h

upstream raw materials:

formaldehyd

2-hydroxy-5-t-butylbenzaldehyde

dimethyl amine

para-tert-butylphenol

Downstream raw materials:

1-(5-tert-butyl-3-formyl-2-hydroxyphenyl)-N,N,N-trimethylmethanammonium iodide