N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide

Base Information

Chemical Name:N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide
CAS No.:930601-47-1
Molecular Formula:C₂₂H₂₃NO₄
Molecular Weight:365.429
Hs Code.:

Synonyms:N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide

Suppliers and Price of N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide

There total 7 articles about N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 809240-72-0
5-(2-aminophenylethynyl)-2,4-dimethoxybenzaldehyde

: 3282-30-2
pivaloyl chloride

: 930601-47-1
N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm0614230

Reference yield:

: 930601-46-0
2-(5-[1,3]dioxolan-2-yl-2,4-dimethoxy-phenyl)-thiazole

: 930601-47-1
N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / water / p-toluenesulfonic acid / acetone / 20 °C

2: 87.5 percent / ICl / methanol / 3 h / 20 °C

3: 92 percent / Et₃N; tetrabutylammonium fluoride / PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 4 h / 20 °C

4: 79 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; tetrabutyl ammonium fluoride; water; Iodine monochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; acetone; 3: Castro-Stephens reaction;
DOI:10.1021/jm0614230

Reference yield:

: 552845-97-3
2,4-dimethoxy-5-thiazol-2-yl-benzaldehyde

: 930601-47-1
N-[2-(5-formyl-2,4-dimethoxyphenylethynyl)phenyl]-2,2-dimethylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87.5 percent / ICl / methanol / 3 h / 20 °C

2: 92 percent / Et₃N; tetrabutylammonium fluoride / PdCl₂(PPh₃)2; CuI / tetrahydrofuran / 4 h / 20 °C

3: 79 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; tetrabutyl ammonium fluoride; Iodine monochloride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; dichloromethane; 2: Castro-Stephens reaction;
DOI:10.1021/jm0614230