3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-[(4-chloro-phenyl)-hydrazono]-3-oxo-propionitrile

Base Information

• Chemical Name: 3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-[(4-chloro-phenyl)-hydrazono]-3-oxo-propionitrile
• CAS No.: 678171-13-6
• Molecular Formula: C₂₅H₁₇Cl₂N₅O₂
• Molecular Weight: 490.348

Synonyms:3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-[(4-chloro-phenyl)-hydrazono]-3-oxo-propionitrile

Chemical Property of 3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-[(4-chloro-phenyl)-hydrazono]-3-oxo-propionitrile

Chemical Property:

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Technology Process of 3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-[(4-chloro-phenyl)-hydrazono]-3-oxo-propionitrile

There total 2 articles about 3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-[(4-chloro-phenyl)-hydrazono]-3-oxo-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

p-chlorobenzenediazonium chloride (2028-74-2) + 3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile (678171-04-5) → 3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-[(4-chloro-phenyl)-hydrazono]-3-oxo-propionitrile (678171-13-6)

Guidance literature:

With sodium acetate; In ethanol; at 0 - 5 ℃; for 3.5h;

DOI:10.1016/S0928-0987(03)00162-3

Reference yield:

ethyl 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one-3-carboxylate (5606-57-5) → 3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-[(4-chloro-phenyl)-hydrazono]-3-oxo-propionitrile (678171-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / sodium hydride / benzene / 8 h / Heating

2: 71 percent / sodium acetate / ethanol / 3.5 h / 0 - 5 °C

With sodium acetate; sodium hydride; In ethanol; benzene;

DOI:10.1016/S0928-0987(03)00162-3

Reference yield: 91.0%

phenylhydrazine (100-63-0) + 3-(7-chloro-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-[(4-chloro-phenyl)-hydrazono]-3-oxo-propionitrile (678171-13-6) → 3-[5-amino-4-(4-chloro-phenylazo)-1-phenyl-1H-pyrazol-3-yl]-7-chloro-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

Guidance literature:

In ethanol; for 2h; Heating;

DOI:10.1016/S0928-0987(03)00162-3

upstream raw materials:

p-chlorobenzenediazonium chloride

3-[7'-chloro-1',3'-dihydro-1'-methyl-5'-phenyl-2'H-1',4'-benzodiazepin-2'-one-3'-yl]-3-oxopropanenitrile

ethyl 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one-3-carboxylate

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