8-methoxy-1-(4-methoxy-benzyl)-6,7-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-e][1,2,4]triazepine

Base Information

Chemical Name:8-methoxy-1-(4-methoxy-benzyl)-6,7-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-e][1,2,4]triazepine
CAS No.:666749-60-6
Molecular Formula:C₁₆H₂₁N₅O₂
Molecular Weight:315.375
Hs Code.:

8-methoxy-1-(4-methoxy-benzyl)-6,7-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-<i>e</i>][1,2,4]triazepine

Synonyms:8-methoxy-1-(4-methoxy-benzyl)-6,7-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-e][1,2,4]triazepine

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Chemical Property of 8-methoxy-1-(4-methoxy-benzyl)-6,7-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-e][1,2,4]triazepine

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Technology Process of 8-methoxy-1-(4-methoxy-benzyl)-6,7-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-e][1,2,4]triazepine

There total 5 articles about 8-methoxy-1-(4-methoxy-benzyl)-6,7-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-e][1,2,4]triazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 67-56-1
methanol

: 306-37-6
N,N'-Dimethylhydrazine dihydrochloride

: 666749-59-3
4-amino-1-p-methoxybenzylimidazole-5-carbaldehyde

: 149-73-5
trimethyl orthoformate

: 666749-60-6
8-methoxy-1-(4-methoxy-benzyl)-6,7-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-e][1,2,4]triazepine

Guidance literature:: Heating;
DOI:10.1021/jm0304257

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 666749-60-6
8-methoxy-1-(4-methoxy-benzyl)-6,7-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-e][1,2,4]triazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / potassium carbonate / dimethylformamide / 20 °C

2: 53 percent / potassium tert-butoxide / dimethylformamide; tetrahydrofuran / -100 °C

3: 61 percent / aq. calcium carbonate / 65 - 75 °C

4: 34 percent / H₂ / Raney nickel / methanol / 3 h / 20 °C / 2327.17 Torr

5: 62 percent / Heating

With potassium tert-butylate; hydrogen; potassium carbonate; calcium carbonate; nickel; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0304257

Reference yield:

: 68019-66-9
1-p-methoxybenzyl-4-nitroimidazole

: 666749-60-6
8-methoxy-1-(4-methoxy-benzyl)-6,7-dimethyl-1,6,7,8-tetrahydro-imidazo[4,5-e][1,2,4]triazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / potassium tert-butoxide / dimethylformamide; tetrahydrofuran / -100 °C

2: 61 percent / aq. calcium carbonate / 65 - 75 °C

3: 34 percent / H₂ / Raney nickel / methanol / 3 h / 20 °C / 2327.17 Torr

4: 62 percent / Heating

With potassium tert-butylate; hydrogen; calcium carbonate; nickel; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0304257