4-Chloro-2-ethoxypyridine

Base Information

• Chemical Name: 4-Chloro-2-ethoxypyridine
• CAS No.: 856851-45-1
• Molecular Formula: C7H8 Cl N O
• Molecular Weight: 157.6
• Hs Code.: 2933399090
• Mol file: 856851-45-1.mol

Synonyms:4-Chloro-2-ethoxypyridine

Chemical Property of 4-Chloro-2-ethoxypyridine

Chemical Property:

• PSA: 22.12000
• LogP: 2.13370
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-chloro-2-ethoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2-ethoxypyridine

There total 3 articles about 4-Chloro-2-ethoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

4-chloro-2-fluoro-pyridine (34941-92-9) + ethanol (64-17-5) → 4-chloro-2-ethoxypyridine (856851-45-1)

Guidance literature:

With sodium; at 50 ℃; for 2h;

DOI:10.1002/hlca.200590104

Reference yield:

2,4-dichloropyridine (26452-80-2) + sodium ethanolate (141-52-6) → 4-chloro-2-ethoxypyridine (856851-45-1)

Guidance literature:

In 1,4-dioxane; at 70 ℃; for 18h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.03.124

Reference yield:

→ 4-chloro-2-ethoxypyridine (856851-45-1)

Guidance literature:

With alkaline solution;

upstream raw materials:

4-chloro-2-fluoro-pyridine

ethanol

2,4-dichloropyridine

sodium ethanolate

Downstream raw materials:

2,3,5-trichloropyridine

5-Chloro-2,4-dihydroxypyridine

2-ethoxy-5-chloro-pyridin-4-ol

2,4-dibromo-5-chloropyridine