C₁₇H₂₀O₄

Base Information

• Chemical Name: C₁₇H₂₀O₄
• CAS No.: 1350895-98-5
• Molecular Formula: C₁₇H₂₀O₄
• Molecular Weight: 288.343
• Mol file: 1350895-98-5.mol

Synonyms:C₁₇H₂₀O₄

Chemical Property of C₁₇H₂₀O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₂₀O₄

There total 4 articles about C₁₇H₂₀O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C17H18O2 (1350895-97-4) → C17H20O4 (1350895-98-5)

Guidance literature:

With methanesulfonamide; AD-mix β; In tetrahydrofuran; water; tert-butyl alcohol; at 0 ℃; for 120h; optical yield given as %ee;

DOI:10.1016/j.bmcl.2011.09.116

Reference yield:

1-Phenyl-2-propyn-1-ol (4187-87-5) → C17H20O4 (1350895-98-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: hydrogen / ethanol / 3 h / 20 °C / Inert atmosphere

3.1: toluene / 31 h / 110 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

4.2: 0 - 20 °C / Inert atmosphere

5.1: AD-mix β; methanesulfonamide / tetrahydrofuran; water; tert-butyl alcohol / 120 h / 0 °C

With methanesulfonamide; di-isopropyl azodicarboxylate; AD-mix β; hydrogen; sodium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; water; toluene; tert-butyl alcohol; 1.1: Mitsunobu reaction / 5.1: Sharpless dihydroxylation;

DOI:10.1016/j.bmcl.2011.09.116

Reference yield:

3-(2-hydroxyphenyl)-1-phenyl-1-propene (24114-57-6) → C17H20O4 (1350895-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: AD-mix β; methanesulfonamide / tetrahydrofuran; water; tert-butyl alcohol / 120 h / 0 °C

With methanesulfonamide; AD-mix β; sodium hydride; In tetrahydrofuran; water; tert-butyl alcohol; 2.1: Sharpless dihydroxylation;

DOI:10.1016/j.bmcl.2011.09.116

upstream raw materials:

C₁₇H₁₈O₂

3-(2-hydroxyphenyl)-1-phenyl-1-propene

1-Phenyl-2-propyn-1-ol

phenol

Downstream raw materials:

(1R,2R)-3-(2-hydroxyphenyl)-1-phenylpropane-1,2-diol

(2R,3S)-2-phenylchroman-3-ol

(2S,3R)-trans-flavan-3-ol

C₂₀H₂₄O₄