(1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one

Base Information

Chemical Name:(1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one
CAS No.:1346004-53-2
Molecular Formula:C₁₅H₁₉NO₂
Molecular Weight:245.321
Hs Code.:

Synonyms:(1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one

Suppliers and Price of (1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one

There total 3 articles about (1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1346004-19-0
(S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate

: 1346004-53-2
(1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one

Guidance literature:: With 15-crown-5; sodium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 8h; optical yield given as %de; stereoselective reaction; Inert atmosphere;
DOI:10.1021/ol202750u

Reference yield:

: 5299-60-5
6-hydroxy-hexanoic acid ethyl ester

: 1346004-53-2
(1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.1: magnesium sulfate / dichloromethane / 0.08 h / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: 15-crown-5; sodium hexamethyldisilazane / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere

With 15-crown-5; sodium hexamethyldisilazane; magnesium sulfate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol202750u

Reference yield:

: 27983-42-2
5-carboethoxypentanal

: 1346004-53-2
(1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium sulfate / dichloromethane / 0.08 h / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: 15-crown-5; sodium hexamethyldisilazane / tetrahydrofuran / 8 h / 20 °C / Inert atmosphere

With 15-crown-5; sodium hexamethyldisilazane; magnesium sulfate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol202750u