6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester
• CAS No.: 155377-05-2
• Molecular Formula: C8H6F3NO2
• Molecular Weight: 205.136
• Hs Code.: 2933399090
• Mol file: 155377-05-2.mol

Synonyms:Methyl 6-(trifluoromethyl)pyridine-2-carboxylate;Methyl 2-(trifluoromethyl)-6-pyridinecarboxylate;Methyl 6-(trifluoromethyl)picolinate;

Chemical Property of 6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester

Chemical Property:

• Vapor Pressure: 0.0584mmHg at 25°C
• Refractive Index: 1.446
• Boiling Point: 232.6 °C at 760 mmHg
• PKA: -0.97±0.10(Predicted)
• Flash Point: 94.5 °C
• PSA: 39.19000
• Density: 1.331 g/cm³
• LogP: 1.88700
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl6-(Trifluoromethyl)picolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 6-(Trifluoromethyl)picolinate is used in the design of a series of substituted pyridines for the treatment of depression.

Technology Process of 6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester

There total 12 articles about 6-Trifluoromethyl-pyridine-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 2-chloro-6-trifluoromethylpyridine (39890-95-4) → 6-(trifluoromethyl)pyridine-2-carboxylic acid methyl ester (155377-05-2)

Guidance literature:

With triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; at 60 ℃; for 17h;

Reference yield: 92.0%

methanol (67-56-1) + 6-(trifluoromethyl)pyridine-2-carboxylic acid (131747-42-7) → 6-(trifluoromethyl)pyridine-2-carboxylic acid methyl ester (155377-05-2)

Guidance literature:

With hydrogenchloride; at 80 ℃;

Reference yield: 80.0%

methyl 6-Bromopicolinate (26218-75-7) + (1,10-phenanthroline)(trifluoromethyl)copper (I) → 6-(trifluoromethyl)pyridine-2-carboxylic acid methyl ester (155377-05-2)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 8h; Sealed tube; Inert atmosphere;

DOI:10.1021/ol500422t

upstream raw materials:

diazomethane

carbon dioxide

2-(trifluoromethyl)pyridine

methanol

Downstream raw materials:

2-(4-fluoro-phenyl)-3-oxo-3-(6-trifluoromethyl-pyridin-2-yl)-propionitrile

2-(4-fluoro-phenyl)-1-(6-trifluoromethyl-pyridin-2-yl)-ethanone

1-[2-(4-Fluoro-phenyl)-1-(6-trifluoromethyl-pyridin-2-yl)-eth-(E)-ylideneamino]-pyrrolidin-2-one

2-(6-trifluoromethyl-pyridin-2-yl)-propan-2-ol