(3S,4S) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone

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Chemical Name:(3S,4S) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone
CAS No.:130865-77-9
Molecular Formula:C₂₀H₂₄N₂O₂
Molecular Weight:324.423
Hs Code.:

Synonyms:(3S,4S) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone

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Chemical Property of (3S,4S) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone

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Technology Process of (3S,4S) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone

There total 14 articles about (3S,4S) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 130865-71-3
(R) 1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole

: 130865-72-4
(3R,4R) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone

: 130865-77-9
(3S,4S) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone

Guidance literature:: With platinum(IV) oxide; hydrogen; acetic acid; In ethyl acetate; at 0 ℃; for 15h;
DOI:10.1016/j.tetlet.2008.07.172

Reference yield:

: 130865-67-7
1-benzyloxy-4-methylpyrrolidin-2-one

: 130865-77-9
(3S,4S) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / potassium bis-trimethylsilylamide, Davis's oxaziridine = Ph-C(O)-N-SO₂Ph / tetrahydrofuran; toluene / 0.5 h / -100 - -91 °C

2: 1) trifluoroacetic anhydride, dimethylsulphoxide, 2) ethyldiisopropylamine / 1) CH₂Cl₂, -78 deg C, 30 min, 2) 45 min

3: 78 percent

4: 1) hydrogen, acetic acid, 2) potassium carbonate / 1) platinum(VI) oxide / 1) ethyl acetate, 1 atm, 14 h, 2) methanol, 3 h

With hydrogen; potassium hexamethylsilazane; potassium carbonate; acetic acid; dimethyl sulfoxide; N-(benzenesulfonyl)-3-phenyloxaziridine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; platinum(VI) oxide; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(01)88493-3

Reference yield:

: 132559-84-3
1-benzyloxy-3-hydroxy-4-methyl-2-pyrrolidinone

: 130865-77-9
(3S,4S) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 1) trifluoroacetic anhydride, dimethylsulphoxide, 2) ethyldiisopropylamine / 1) CH₂Cl₂, -78 deg C, 30 min, 2) 45 min

2: 78 percent

3: 1) hydrogen, acetic acid, 2) potassium carbonate / 1) platinum(VI) oxide / 1) ethyl acetate, 1 atm, 14 h, 2) methanol, 3 h

With hydrogen; potassium carbonate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; platinum(VI) oxide;
DOI:10.1016/S0040-4020(01)88493-3