132559-84-3

Upstream product

• 100-39-0 benzyl bromide 
• 114839-28-0 4,4-Dimethoxy-3-methyl-butyric acid ethyl ester 
• 70423-44-8 (Z)-4,4-Dimethoxy-3-methyl-crotonsaeureaethylester 
• 144564-41-0 4-Benzyloxyamino-3-methyl-butyric acid ethyl ester 
• 130865-67-7 1-benzyloxy-4-methylpyrrolidin-2-one 
• 113548-13-3 N-(benzenesulfonyl)-3-phenyloxaziridine 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 54998-57-1 ethyl 3-formylbutyrate 
• 130865-74-6 4-[(E)-Benzyloxyimino]-3-methyl-butyric acid ethyl ester 
• 622-33-3 N-benzyloxyamine 

Downstream Products

• 130865-70-2 1-benzyloxy-4-methyl-pyrrolidine-2,2-dione 
• 130865-71-3 (R) 1-benzyloxy-4-methyl-2-oxo-3-(1-phenylethylamino)-2,5-dihydropyrrole 
• 130931-65-6 (3R,4R)-3-amino-1-hydroxy-4-methylpyrrolidin-2-one 
• 132695-96-6 3S-amino-1-hydroxy-4S-methylpyrrolidin-2-one 
• 130865-72-4 (3R,4R) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone 
• 130865-77-9 (3S,4S) 1-benzyloxy-4-methyl-3-<(R)-1-phenylethylamino>-2-pyrrolidinone 

Relevant academic research and scientific papers

Routes to 4-Substituted Analogues of the Glycine/NMDA Antagonist HA-966. Enantioselective Synthesis of (3R,4R) 3-Amino-1-Hydroxy-4-Methyl-2-Pyrrolidinone (L-687,414).

Glycine anion (4) and glycine cation (8) synthons are used in efficient synthesis of 4-substituted analogues of HA-966 (1).A stereospecific route to cis derivatives involves hydrogenation of enamines such as 16.Introduction of a chiral auxiliary leads to

Hydrocarbon substituted pyrrolidinones, intermediates therefor, and anti-convulsant use thereof

Compounds of formula (I) and pharmaceutically acceptable acid addition salts thereof: STR1 wherein R represents a hydrocarbon group, X represents oxygen or sulphur, and R and --NH2 are cis; are of use in the treatment and/or prevention of neuro