130865-71-3Relevant academic research and scientific papers
A short and efficient synthesis of the NMDA glycine site antagonist: (3R,4R)-3-amino-1-hydroxy-4-methyl pyrrolidin-2-one (L-687,414)
Pinard, Emmanuel,Burner, Serge,Cueni, Philippe,Montavon, Fran?ois,Zimmerli, Daniel
experimental part, p. 6079 - 6080 (2009/04/11)
A short and efficient synthesis of the NMDA glycine site antagonist: (3R,4R)-3-amino-1-hydroxy-4-methyl pyrrolidin-2-one (L-687,414) is described.
Routes to 4-Substituted Analogues of the Glycine/NMDA Antagonist HA-966. Enantioselective Synthesis of (3R,4R) 3-Amino-1-Hydroxy-4-Methyl-2-Pyrrolidinone (L-687,414).
Rowley, Michael,Leeson, Paul D.,Williams, Brian J.,Moore, Kevin W.,Baker, Raymond
, p. 3557 - 3570 (2007/10/02)
Glycine anion (4) and glycine cation (8) synthons are used in efficient synthesis of 4-substituted analogues of HA-966 (1).A stereospecific route to cis derivatives involves hydrogenation of enamines such as 16.Introduction of a chiral auxiliary leads to
Hydrocarbon substituted pyrrolidinones, intermediates therefor, and anti-convulsant use thereof
-
, (2008/06/13)
Compounds of formula (I) and pharmaceutically acceptable acid addition salts thereof: STR1 wherein R represents a hydrocarbon group, X represents oxygen or sulphur, and R and --NH2 are cis; are of use in the treatment and/or prevention of neuro
