ethyl 4‐[4‐(benzyloxy)phenyl]‐6‐methyl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate

Base Information

Chemical Name:ethyl 4‐[4‐(benzyloxy)phenyl]‐6‐methyl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate
CAS No.:294197-68-5
Molecular Formula:C₂₁H₂₂N₂O₄
Molecular Weight:366.417
Hs Code.:

Synonyms:ethyl 4‐[4‐(benzyloxy)phenyl]‐6‐methyl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate

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Chemical Property of ethyl 4‐[4‐(benzyloxy)phenyl]‐6‐methyl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate

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Technology Process of ethyl 4‐[4‐(benzyloxy)phenyl]‐6‐methyl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate

There total 4 articles about ethyl 4‐[4‐(benzyloxy)phenyl]‐6‐methyl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 4397-53-9
p-benzyloxybenzaldehyde

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 294197-68-5
ethyl 4‐[4‐(benzyloxy)phenyl]‐6‐methyl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate

Guidance literature:: With lanthanum(lll) triflate; In ethanol; at 100 ℃; for 1h; Solvent; Green chemistry;
DOI:10.1002/ardp.202000466

Reference yield:

: 123629-41-4
ethyl 4-(4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 100-39-0
benzyl bromide

: 294197-68-5
ethyl 4‐[4‐(benzyloxy)phenyl]‐6‐methyl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;
DOI:10.1038/aps.2016.32

Reference yield:

: 100-52-7
benzaldehyde

: 294197-68-5
ethyl 4‐[4‐(benzyloxy)phenyl]‐6‐methyl‐2‐oxo‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C

1.2: 1 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

With sodium tetrahydroborate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; 2.1: |Williamson Ether Synthesis;
DOI:10.1038/aps.2016.32