ethyl 4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate

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Chemical Name:ethyl 4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate
CAS No.:1296654-82-4
Molecular Formula:C₁₈H₁₈N₂O₄
Molecular Weight:326.352
Hs Code.:

Synonyms:ethyl 4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate

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Chemical Property of ethyl 4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate

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Technology Process of ethyl 4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate

There total 9 articles about ethyl 4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1296654-80-2
1,6-dimethyl-5-phenyl-4H-pyrrolo[1,2-d][1,3,4]oxadiazine-2,4(1H)-dione

: 105-53-3
diethyl malonate

: 1296654-82-4
ethyl 4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate

Guidance literature:: diethyl malonate; With sodium hydride; In N,N-dimethyl acetamide; for 0.166667h; Inert atmosphere;

1,6-dimethyl-5-phenyl-4H-pyrrolo[1,2-d][1,3,4]oxadiazine-2,4(1H)-dione; In N,N-dimethyl acetamide; at 120 ℃; for 12h;

Reference yield:

: 100-52-7
benzaldehyde

: 1296654-82-4
ethyl 4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: ammonium acetate; acetic acid / 5 h / Reflux

2.1: potassium carbonate / tetrahydrofuran / 16 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 0.5 h

4.1: triethylamine / dichloromethane / 2 h / 20 °C

5.1: potassium carbonate / acetonitrile / 0.5 h / 0 - 10 °C

5.2: 10 h / 20 °C

6.1: sodium ethanolate; ethanol / 1 h / 10 - 20 °C

7.1: potassium hydroxide; water / ethanol / 3 h / Reflux

7.2: pH 6

8.1: 1,4-dioxane / 10 h / 20 °C

9.1: sodium hydride / N,N-dimethyl acetamide / 0.17 h / Inert atmosphere

9.2: 12 h / 120 °C

With ethanol; ammonium acetate; water; sodium ethanolate; sodium hydride; potassium carbonate; acetic acid; triethylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 124901-12-8
ethyl 4-methyl-3-phenyl-1H-pyrrole-2-carboxylate

: 1296654-82-4
ethyl 4-hydroxy-1,6-dimethyl-2-oxo-5-phenyl-1,2-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

1.2: 0.5 h

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: potassium carbonate / acetonitrile / 0.5 h / 0 - 10 °C

3.2: 10 h / 20 °C

4.1: sodium ethanolate; ethanol / 1 h / 10 - 20 °C

5.1: potassium hydroxide; water / ethanol / 3 h / Reflux

5.2: pH 6

6.1: 1,4-dioxane / 10 h / 20 °C

7.1: sodium hydride / N,N-dimethyl acetamide / 0.17 h / Inert atmosphere

7.2: 12 h / 120 °C

With ethanol; water; sodium ethanolate; sodium hydride; potassium carbonate; triethylamine; potassium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; acetonitrile;