(2-hydroxy-3-methylbutyl)methylphenylphosphine oxide

Base Information

• Chemical Name: (2-hydroxy-3-methylbutyl)methylphenylphosphine oxide
• CAS No.: 311806-48-1
• Molecular Formula: C₁₂H₁₉O₂P
• Molecular Weight: 226.255
• Mol file: 311806-48-1.mol

Synonyms:(2-hydroxy-3-methylbutyl)methylphenylphosphine oxide

Chemical Property of (2-hydroxy-3-methylbutyl)methylphenylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2-hydroxy-3-methylbutyl)methylphenylphosphine oxide

There total 3 articles about (2-hydroxy-3-methylbutyl)methylphenylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

dimethyl(phenyl)phosphine oxide (10311-08-7) + isobutyraldehyde (78-84-2) → (2-hydroxy-3-methylbutyl)methylphenylphosphine oxide (311806-48-1)

Guidance literature:

dimethyl(phenyl)phosphine oxide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.833333h; Inert atmosphere; Schlenk technique;

isobutyraldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tet.2016.06.070

Reference yield:

Dimethyl(phenyl)phosphine (672-66-2) → (2-hydroxy-3-methylbutyl)methylphenylphosphine oxide (311806-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: H₂O₂

2.1: BuLi / tetrahydrofuran; hexane / 1 h

2.2: 37.1 g / tetrahydrofuran; hexane / 15 h / -78 - 20 °C

With n-butyllithium; dihydrogen peroxide; In tetrahydrofuran; hexane; 1.1: Oxidation / 2.1: Metallation / 2.2: Alkylation;

DOI:10.1039/b004525j

Reference yield:

1-(2-Hydroxy-3-methylbutyl)-4,4-dimethyl-1,2,3,4-tetrahydrophosphinoline oxide (311806-50-5) → (2-hydroxy-3-methylbutyl)methylphenylphosphine oxide (311806-48-1) + 1,4,4-trimethyl-1,2,3,4-tetrahydrophosphinoline-1-oxide (311806-49-2) + 1,1,6,6-Tetramethyl-2,3,6,7-tetrahydro-1H,5H-benzo[ij]phosphinolizine oxide (311806-51-6)

Guidance literature:

With PPA; at 120 ℃; for 120h; Title compound not separated from byproducts.;

DOI:10.1039/b004525j

upstream raw materials:

dimethyl(phenyl)phosphine oxide

isobutyraldehyde

1-(2-Hydroxy-3-methylbutyl)-4,4-dimethyl-1,2,3,4-tetrahydrophosphinoline oxide

Dimethyl(phenyl)phosphine

Downstream raw materials:

1,4,4-trimethyl-1,2,3,4-tetrahydrophosphinoline-1-oxide