10311-08-7

Basic information

• Product Name: dimethyl(phenyl)phosphane oxide
• CAS NO: 10311-08-7
• Molecular Formula: C₈H₁₁OP
• Molecular Weight: 154.1461
• Mol File: 10311-08-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 298.8°C at 760 mmHg
• Flash Point: 134.5°C
• Density: 1.03g/cm³
• Vapor Pressure: 0.00221mmHg at 25°C
• Refractive Index: 1.486
• CAS DataBase Reference: dimethyl(phenyl)phosphane oxide(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl(phenyl)phosphane oxide(10311-08-7)
• EPA Substance Registry System: dimethyl(phenyl)phosphane oxide(10311-08-7)

Safety Data

• Hazardous Substances Data: 10311-08-7(Hazardous Substances Data)

Upstream product

• 917-64-6 methyl magnesium iodide 
• 644-97-3 Dichlorophenylphosphine 
• 7175-54-4 cumyl peroxy radical 
• 672-66-2 Dimethyl(phenyl)phosphine 
• 591-50-4 iodobenzene 
• 7211-39-4 dimethyl phosphine oxide 
• 917-54-4 methyllithium 
• 791-28-6 Triphenylphosphine oxide 
• 2946-61-4 phenylphosphonous acid dimethyl ester 
• 2240-41-7 dimethyl phenylphosphonate 
• 75-16-1 methylmagnesium bromide 
• 6389-79-3 methyl methylphenylphosphinate 
• 676-58-4 methylmagnesium chloride 
• 3049-24-9 diphenyl phenylphosphonate 

Downstream Products

• 210627-74-0 2-{[2,2-Bis-(4-chloro-phenyl)-2-hydroxy-ethyl]-phenyl-phosphinoyl}-1,1-bis-(4-chloro-phenyl)-ethanol 
• 311806-48-1 (2-hydroxy-3-methylbutyl)methylphenylphosphine oxide 
• 1344732-79-1 (1,4-cyclohexadien-3-yl)dimethylphosphine oxide 
• 105992-52-7 Np(NCS)4(P(CH₃)2(C₆H₅)O)4 
• 105992-58-3 Pu(NCS)4(P(CH₃)2(C₆H₅)O)4 
• 105992-59-4 Pu(NCS)4(P(CH₃)(C₆H₅)2O)4 
• 117319-07-0 {PPh₃(cyclo-C₆H₁₁)}tribromo(dimethylphenylphosphine oxide) manganese(II) 
• 156298-75-8 1,5-dioxa-4Λ⁵-phosphaspiro<3.3>heptane 
• 210627-95-5 2,2,6,6-Tetrakis-(4-nitro-phenyl)-4-phenyl-1,5-dioxa-4λ⁵-phospha-spiro[3.3]heptane 
• 210627-92-2 2,2,6,6-Tetrakis-(4-chloro-phenyl)-4-phenyl-1,5-dioxa-4λ⁵-phospha-spiro[3.3]heptane 
• 210627-89-7 2,2,6,6-Tetrakis-(4-fluoro-phenyl)-4-phenyl-1,5-dioxa-4λ⁵-phospha-spiro[3.3]heptane 

Relevant articles and documents

Aryl group - A leaving group in arylphosphine oxides

The treatment of triphenylphosphine oxide with organometallic reagents leads to the substitution of up to three phenyl substituents with the incoming carbon nucleophile. The replacement of the phenyl/aryl group in tertiary diarylalkylphosphine oxides or even aryldialkylphosphine oxides was also observed. Naphthyl-substituted phosphine oxides undergo Michael-type addition at the naphthyl group when treated with organolithium reagent.

Michael-type addition of secondary phosphine oxides to (1,4-cyclohexadien- 3-yl)phosphine oxides

Base-induced reaction between (1,4-cyclohexadien-3-yl)phosphine oxides and secondary phosphine oxides gives 3,4-bis(phosphinoyl)cyclohexenes and 2,3-bis(phosphinoyl)cyclohexenes through an in situ isomerization of one of the cyclohexadienyl double bonds and a subsequent Michael-type addition of the secondary phosphine oxide.

Sodium in liquid ammonia - A versatile tool in modifications of arylphosphine oxides

A simple and practical method for modifications of tertiary arylphosphine oxides based on their reaction with sodium in liquid ammonia is presented. Depending on the structure of the starting compounds, either dearomatisation of the phenyl substituent or cleavage of a P-aryl bond from phosphorus atom can be selectively performed and the corresponding (1,4-cyclohexadien-3-yl)phosphine oxides or secondary phosphine oxides were obtained in good to excellent yields.