2,3-dihydro-2-(dimethylylidenmalonate)-5-phenyl-1H-1,4-benzodiazepine

Base Information

• Chemical Name: 2,3-dihydro-2-(dimethylylidenmalonate)-5-phenyl-1H-1,4-benzodiazepine
• CAS No.: 608136-46-5
• Molecular Formula: C₂₀H₁₈N₂O₄
• Molecular Weight: 350.374
• Mol file: 608136-46-5.mol

Synonyms:2,3-dihydro-2-(dimethylylidenmalonate)-5-phenyl-1H-1,4-benzodiazepine

Chemical Property of 2,3-dihydro-2-(dimethylylidenmalonate)-5-phenyl-1H-1,4-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dihydro-2-(dimethylylidenmalonate)-5-phenyl-1H-1,4-benzodiazepine

There total 1 articles about 2,3-dihydro-2-(dimethylylidenmalonate)-5-phenyl-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one (2898-08-0) + malonic acid dimethyl ester (108-59-8) → 2,3-dihydro-2-(dimethylylidenmalonate)-5-phenyl-1H-1,4-benzodiazepine (608136-46-5)

Guidance literature:

malonic acid dimethyl ester; With sodium hydride; In 1,2-dimethoxyethane; at 0 ℃; for 1h;

With diethyl chlorophosphate; In 1,2-dimethoxyethane; for 0.5h;

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one; In 1,2-dimethoxyethane; at 20 ℃; for 14h;

DOI:10.1021/jm0307640

Reference yield: 67.0%

2,3-dihydro-2-(dimethylylidenmalonate)-5-phenyl-1H-1,4-benzodiazepine (608136-46-5) → (Z)-2,3-dihydro-2-[(methoxycarbonyl)methylen]-5-phenyl-1H-1,4-benzodiazepine (608136-48-7)

Guidance literature:

With sodium hydroxide; In methanol; at 20 - 60 ℃; for 13h;

DOI:10.1021/jm0307640

Reference yield:

2,3-dihydro-2-(dimethylylidenmalonate)-5-phenyl-1H-1,4-benzodiazepine (608136-46-5) → (2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin)-2-acetic acid methyl ester (608136-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / aq. NaOH / methanol / 13 h / 20 - 60 °C

2: 64 percent / aq. NaOH; Bu₄NBr / benzene / 3 h / Heating

3: 84 percent / TFA; triethylsilane / 0.5 h / 20 °C

With triethylsilane; sodium hydroxide; tetrabutylammomium bromide; trifluoroacetic acid; In methanol; benzene;

DOI:10.1021/jm0307640

upstream raw materials:

2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one

malonic acid dimethyl ester

Downstream raw materials:

(Z)-2,3-dihydro-2-[(methoxycarbonyl)methylen]-5-phenyl-1H-1,4-benzodiazepine

2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine