(E)-N'-(3-(4-methoxyphenyl)acryloyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbohydrazide

Base Information

Chemical Name:(E)-N'-(3-(4-methoxyphenyl)acryloyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbohydrazide
CAS No.:1615678-15-3
Molecular Formula:C₁₉H₁₈N₂O₅
Molecular Weight:354.362
Hs Code.:

Synonyms:(E)-N'-(3-(4-methoxyphenyl)acryloyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbohydrazide

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Chemical Property of (E)-N'-(3-(4-methoxyphenyl)acryloyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbohydrazide

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Technology Process of (E)-N'-(3-(4-methoxyphenyl)acryloyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbohydrazide

There total 4 articles about (E)-N'-(3-(4-methoxyphenyl)acryloyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98953-13-0
2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid hydrazide

: 943-89-5
(E)-3-(4-methoxyphenyl)acrylic acid

: 1615678-15-3
(E)-N'-(3-(4-methoxyphenyl)acryloyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbohydrazide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1016/j.ejmech.2014.05.026

Reference yield:

: 2150-43-8
3,4-dihydroxybenzoic acid methyl ester

: 1615678-15-3
(E)-N'-(3-(4-methoxyphenyl)acryloyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 24 h / Inert atmosphere; Reflux

2: hydrazine hydrate / ethanol / 120 h / 90 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 8 h / 20 °C

With hydrazine hydrate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; acetone;
DOI:10.1016/j.ejmech.2014.05.026

Reference yield:

: 99-50-3
3,4-Dihydroxybenzoic acid

: 1615678-15-3
(E)-N'-(3-(4-methoxyphenyl)acryloyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 8 h / 90 °C

2: potassium carbonate / acetone / 24 h / Inert atmosphere; Reflux

3: hydrazine hydrate / ethanol / 120 h / 90 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 8 h / 20 °C

With hydrazine hydrate; sulfuric acid; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; acetone;
DOI:10.1016/j.ejmech.2014.05.026