benzyl 4-(2-chloroethyl)-3-[5,6,7-trimethoxyindole-2-carboxamido]phenyl ether

Base Information

Chemical Name:benzyl 4-(2-chloroethyl)-3-[5,6,7-trimethoxyindole-2-carboxamido]phenyl ether
CAS No.:413578-29-7
Molecular Formula:C₂₇H₂₇ClN₂O₅
Molecular Weight:494.975
Hs Code.:

Synonyms:benzyl 4-(2-chloroethyl)-3-[5,6,7-trimethoxyindole-2-carboxamido]phenyl ether

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Chemical Property of benzyl 4-(2-chloroethyl)-3-[5,6,7-trimethoxyindole-2-carboxamido]phenyl ether

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Technology Process of benzyl 4-(2-chloroethyl)-3-[5,6,7-trimethoxyindole-2-carboxamido]phenyl ether

There total 6 articles about benzyl 4-(2-chloroethyl)-3-[5,6,7-trimethoxyindole-2-carboxamido]phenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 128781-07-7
5,6,7-trimethoxy-1H-indole-2-carboxylic acid

: 413577-26-1
2-(2-amino-4-benzyloxyphenyl)ethyl chloride

: 413578-29-7
benzyl 4-(2-chloroethyl)-3-[5,6,7-trimethoxyindole-2-carboxamido]phenyl ether

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2004.08.051

Reference yield:

: 6860-79-3
4-benzyloxy-2-nitrophenylacetic acid

: 413578-29-7
benzyl 4-(2-chloroethyl)-3-[5,6,7-trimethoxyindole-2-carboxamido]phenyl ether

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / borane / tetrahydrofuran / 4 h / 20 °C

2: 97 percent / triphenylphosphine; CCl₄ / CH₂Cl₂

3: H₂ / PtO₂ / tetrahydrofuran / 1 h / 2844.31 Torr

4: 66 percent / PyBOP; N,N-diisopropylethylamine / CH₂Cl₂ / 20 °C

With tetrachloromethane; borane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2004.08.051

Reference yield:

: 112089-51-7
diethyl <4-(benzyloxy)-2-nitrophenyl>malonate

: 413578-29-7
benzyl 4-(2-chloroethyl)-3-[5,6,7-trimethoxyindole-2-carboxamido]phenyl ether

Guidance literature:: Multi-step reaction with 6 steps

1: NaOH / ethanol / 3 h / Heating

2: 1.41 g / HCl / tetrahydrofuran; H₂O / 1 h / pH 1 / Heating

3: 95 percent / borane / tetrahydrofuran / 4 h / 20 °C

4: 97 percent / triphenylphosphine; CCl₄ / CH₂Cl₂

5: H₂ / PtO₂ / tetrahydrofuran / 1 h / 2844.31 Torr

6: 66 percent / PyBOP; N,N-diisopropylethylamine / CH₂Cl₂ / 20 °C

With hydrogenchloride; tetrachloromethane; sodium hydroxide; borane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2004.08.051