413577-26-1Relevant articles and documents
Sequence specific recognition of DNA by tailor-made hairpin conjugates of achiral seco-cyclopropaneindoline-2-benzofurancarboxamide and pyrrole-imidazole polyamides
Price, Carly A.,Lingerfelt, Brian M.,Handl, Heather L.,Kiakos, Konstantinos,Hartley, John A.,Lee, Moses
, p. 3151 - 3156 (2007/10/03)
Hairpin conjugates of achiral seco-cyclopropaneindoline-2- benzofurancarboxamide (achiral seco-CI-Bf) and three diamides (ImPy 1, PyIm 2, and PyPy 3, where Py is pyrrole, and Im is imidazole), linked by a γ-aminobutyrate group, were synthesized. The seque
Compositions and methods of the use thereof achiral analogues of CC-1065 and the duocarmycins
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, (2008/06/13)
The present invention relates to novel achiral seco-analogues of the DNA minor groove and sequence-selective alkylating agents (+)-CC1065 and the duocarmycins, depicted as general class I, II III, IV and V: wherein X is a good leaving group, such as a chl