tert-Butyl 4-hydroxy-4-[(methylamino)-methyl]piperidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-hydroxy-4-[(methylamino)-methyl]piperidine-1-carboxylate
• CAS No.: 1073559-55-3
• Molecular Formula: C₁₂H₂₄N₂O₃
• Molecular Weight: 244.334
• Hs Code.: 2933399990
• Mol file: 1073559-55-3.mol

Synonyms:tert-butyl 4-hydroxy-4-((methylamino)methyl)piperidine-1-carboxylate

Chemical Property of tert-Butyl 4-hydroxy-4-[(methylamino)-methyl]piperidine-1-carboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 4-hydroxy-4-[(methylamino)methyl]piperidine-1-carboxylate ^*data from reagent suppliers

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Technology Process of tert-Butyl 4-hydroxy-4-[(methylamino)-methyl]piperidine-1-carboxylate

There total 1 articles about tert-Butyl 4-hydroxy-4-[(methylamino)-methyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methylamine (74-89-5) + 1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester (147804-30-6) → tert-butyl 4-hydroxy-4-((methylamino)methyl)piperidine-1-carboxylate (1073559-55-3)

Guidance literature:

In ethanol; water; at 20 ℃; for 16h;

DOI:10.1021/acs.jmedchem.0c01127

Reference yield: 71.0%

tert-butyl 4-hydroxy-4-((methylamino)methyl)piperidine-1-carboxylate (1073559-55-3) + chloroacetyl chloride (79-04-9) → tert-butyl 4-((2-chloro-N-methylacetamido)methyl)-4-hydroxypiperidine-1-carboxylate

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 8h;

DOI:10.1021/acs.jmedchem.0c01411

Reference yield:

tert-butyl 4-hydroxy-4-((methylamino)methyl)piperidine-1-carboxylate (1073559-55-3) + benzenesulfonyl chloride (98-09-9) → tert-butyl 4-hydroxy-4-{[methyl(phenylsulfonyl)amino]methyl}piperidine-1-carboxylate

Guidance literature:

With potassium carbonate; In acetonitrile; at 25 ℃; for 3h;

upstream raw materials:

methylamine

1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester

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