(S)-N-methoxy-N-methyl-2-(4-methylphenylsulfonamido)-2-phenylacetamide

Base Information

• Chemical Name: (S)-N-methoxy-N-methyl-2-(4-methylphenylsulfonamido)-2-phenylacetamide
• CAS No.: 1019853-28-1
• Molecular Formula: C₁₇H₂₀N₂O₄S
• Molecular Weight: 348.423

Synonyms:(S)-N-methoxy-N-methyl-2-(4-methylphenylsulfonamido)-2-phenylacetamide

Chemical Property of (S)-N-methoxy-N-methyl-2-(4-methylphenylsulfonamido)-2-phenylacetamide

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Technology Process of (S)-N-methoxy-N-methyl-2-(4-methylphenylsulfonamido)-2-phenylacetamide

There total 2 articles about (S)-N-methoxy-N-methyl-2-(4-methylphenylsulfonamido)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2S)-2-phenyl-2-(tosylamino)acetic acid (111524-98-2) + N,0-dimethylhydroxylamine (1117-97-1) → (S)-N-methoxy-N-methyl-2-(4-methylphenylsulfonamido)-2-phenylacetamide (1019853-28-1)

Guidance literature:

(2S)-2-phenyl-2-(tosylamino)acetic acid; N,0-dimethylhydroxylamine; In toluene; at 0 ℃; for 0.166667h;

With phosphorus trichloride; In toluene; at 20 - 60 ℃; for 0.5h;

DOI:10.1055/s-0033-1340317

Reference yield: 67.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + (2S)-2-phenyl-2-(tosylamino)acetic acid (111524-98-2) → (S)-N-methoxy-N-methyl-2-(4-methylphenylsulfonamido)-2-phenylacetamide (1019853-28-1)

Guidance literature:

With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -15 ℃; for 4.5h; Inert atmosphere;

DOI:10.1021/ol800318h

Reference yield: 62.0%

(S)-N-methoxy-N-methyl-2-(4-methylphenylsulfonamido)-2-phenylacetamide (1019853-28-1) + phenylmagnesium bromide (100-58-3) → (S)-N1-(1-methyl-2-oxo-2-phenylethyl)-4-methyl-1-benzenesulfonamide (863016-80-2)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol800318h

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

(2S)-2-phenyl-2-(tosylamino)acetic acid

N,0-dimethylhydroxylamine

Downstream raw materials:

(S)-N₁-(1-methyl-2-oxo-2-phenylethyl)-4-methyl-1-benzenesulfonamide

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