(E)-(4S,5S)-7-Benzyloxy-4-methyl-5-triethylsilanyloxy-hept-2-enoic acid ethyl ester

Base Information

Chemical Name:(E)-(4S,5S)-7-Benzyloxy-4-methyl-5-triethylsilanyloxy-hept-2-enoic acid ethyl ester
CAS No.:179945-12-1
Molecular Formula:C₂₃H₃₈O₄Si
Molecular Weight:406.638
Hs Code.:

Synonyms:(E)-(4S,5S)-7-Benzyloxy-4-methyl-5-triethylsilanyloxy-hept-2-enoic acid ethyl ester

Suppliers and Price of (E)-(4S,5S)-7-Benzyloxy-4-methyl-5-triethylsilanyloxy-hept-2-enoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-(4S,5S)-7-Benzyloxy-4-methyl-5-triethylsilanyloxy-hept-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-(4S,5S)-7-Benzyloxy-4-methyl-5-triethylsilanyloxy-hept-2-enoic acid ethyl ester

There total 6 articles about (E)-(4S,5S)-7-Benzyloxy-4-methyl-5-triethylsilanyloxy-hept-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 994-30-9
triethylsilyl chloride

: 179945-12-1
(E)-(4S,5S)-7-Benzyloxy-4-methyl-5-triethylsilanyloxy-hept-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / imidazole / dimethylformamide / 0.58 h / 23 °C

2: 98 percent / diisobutylaluminum hydride / tetrahydrofuran; hexane / 1.5 h / -78 °C

3: 1.) potassium tert-butoxide / 1.) THF, room temperature, 1 h, 2.) THF, -78 -> 0 deg C

With 1H-imidazole; potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo9606113

Reference yield:

: 19790-60-4
3-Benzyloxypropanal

: 179945-12-1
(E)-(4S,5S)-7-Benzyloxy-4-methyl-5-triethylsilanyloxy-hept-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) dibutylboron triflate, triethylamine / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, -78 -> 0 deg C

2: 1.) trimethylaluminum / 1.) THF, toluene, 0 deg C -> room temperature, 2.) THF, toluene, CH₂Cl₂, -10 -> 0 deg C

3: 100 percent / imidazole / dimethylformamide / 0.58 h / 23 °C

4: 98 percent / diisobutylaluminum hydride / tetrahydrofuran; hexane / 1.5 h / -78 °C

5: 1.) potassium tert-butoxide / 1.) THF, room temperature, 1 h, 2.) THF, -78 -> 0 deg C

With 1H-imidazole; di-n-butylboryl trifluoromethanesulfonate; potassium tert-butylate; trimethylaluminum; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jo9606113

Reference yield:

: 157220-40-1
(2R,3S)-5-Benzyloxy-2-methyl-3-triethylsilanyloxy-pentanoic acid methoxy-methyl-amide

: 179945-12-1
(E)-(4S,5S)-7-Benzyloxy-4-methyl-5-triethylsilanyloxy-hept-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / diisobutylaluminum hydride / tetrahydrofuran; hexane / 1.5 h / -78 °C

2: 1.) potassium tert-butoxide / 1.) THF, room temperature, 1 h, 2.) THF, -78 -> 0 deg C

With potassium tert-butylate; diisobutylaluminium hydride; In tetrahydrofuran; hexane;
DOI:10.1021/jo9606113