N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethyl]-2-methylpropane-2-(S)-sulfinamide

Base Information

Chemical Name:N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethyl]-2-methylpropane-2-(S)-sulfinamide
CAS No.:1283090-78-7
Molecular Formula:C₂₄H₃₄F₄N₂O₂SSi
Molecular Weight:518.691
Hs Code.:

Synonyms:N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethyl]-2-methylpropane-2-(S)-sulfinamide

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Chemical Property of N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethyl]-2-methylpropane-2-(S)-sulfinamide

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Technology Process of N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethyl]-2-methylpropane-2-(S)-sulfinamide

There total 5 articles about N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethyl]-2-methylpropane-2-(S)-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1189175-91-4
N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoro-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-(S)-sulfinamide

: 1283090-78-7
N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethyl]-2-methylpropane-2-(S)-sulfinamide

Guidance literature:: With sodium acetate; magnesium; acetic acid; In water; N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1283090-78-7
N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethyl]-2-methylpropane-2-(S)-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

2.2: 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

4.1: sodium acetate; magnesium; acetic acid / N,N-dimethyl-formamide; water / 4 h / 20 °C

With 1H-imidazole; titanium(IV) tetraethanolate; sodium acetate; magnesium; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 1017599-17-5
(3,4-difluorophenyl)[5-(hydroxymethyl)-2-pyridinyl]methanone

: 1283090-78-7
N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2-difluoroethyl]-2-methylpropane-2-(S)-sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / tetrahydrofuran / 1 h / 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / Reflux

2.2: 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

4.1: sodium acetate; magnesium; acetic acid / N,N-dimethyl-formamide; water / 4 h / 20 °C

With 1H-imidazole; titanium(IV) tetraethanolate; sodium acetate; magnesium; acetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; water; N,N-dimethyl-formamide;