(R)-N-(2-chloroacetyl)-3-chlorophenylalanine methyl ester

Base Information

• Chemical Name: (R)-N-(2-chloroacetyl)-3-chlorophenylalanine methyl ester
• CAS No.: 1610691-83-2
• Molecular Formula: C₁₂H₁₃Cl₂NO₃
• Molecular Weight: 290.146
• Mol file: 1610691-83-2.mol

Synonyms:(R)-N-(2-chloroacetyl)-3-chlorophenylalanine methyl ester

Chemical Property of (R)-N-(2-chloroacetyl)-3-chlorophenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-N-(2-chloroacetyl)-3-chlorophenylalanine methyl ester

There total 2 articles about (R)-N-(2-chloroacetyl)-3-chlorophenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-chlorophenylalanine methyl ester hydrochloride (457654-75-0) + chloroacetyl chloride (79-04-9) → (R)-N-(2-chloroacetyl)-3-chlorophenylalanine methyl ester (1610691-83-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

DOI:10.1016/j.tet.2014.04.045

Reference yield:

(R)-2-amino-3-(3-chlorophenyl)propanoic acid (80126-52-9) → (R)-N-(2-chloroacetyl)-3-chlorophenylalanine methyl ester (1610691-83-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetyl chloride / 0.25 h / 0 °C

1.2: 38 h / Reflux

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

With triethylamine; acetyl chloride; In dichloromethane;

DOI:10.1016/j.tet.2014.04.045

Reference yield: 66.0%

(R)-N-(2-chloroacetyl)-3-chlorophenylalanine methyl ester (1610691-83-2) + 2,2-dimethoxyethylamine (22483-09-6) → (R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-3-chlorophenylalanine methyl ester (1610691-88-7)

Guidance literature:

With sodium iodide; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1016/j.tet.2014.04.045

upstream raw materials:

(R)-2-amino-3-(3-chlorophenyl)propanoic acid

(R)-3-chlorophenylalanine methyl ester hydrochloride

chloroacetyl chloride

Downstream raw materials:

(R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-3-chlorophenylalanine methyl ester