tert-Butyl 3-[N-benzyl-N-(4-methoxybenzyl)amino]-3-phenylpropanoate

Base Information

• Chemical Name: tert-Butyl 3-[N-benzyl-N-(4-methoxybenzyl)amino]-3-phenylpropanoate
• CAS No.: 265669-70-3
• Molecular Formula: C₂₈H₃₃NO₃
• Molecular Weight: 431.575
• Mol file: 265669-70-3.mol

Synonyms:tert-Butyl 3-[N-benzyl-N-(4-methoxybenzyl)amino]-3-phenylpropanoate

Chemical Property of tert-Butyl 3-[N-benzyl-N-(4-methoxybenzyl)amino]-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl 3-[N-benzyl-N-(4-methoxybenzyl)amino]-3-phenylpropanoate

There total 4 articles about tert-Butyl 3-[N-benzyl-N-(4-methoxybenzyl)amino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butyl cinnamate (14990-09-1) + benzyl-(4-methoxybenzyl)amine (14429-02-8) → tert-Butyl 3-[N-benzyl-N-(4-methoxybenzyl)amino]-3-phenylpropanoate (265669-70-3)

Guidance literature:

benzyl-(4-methoxybenzyl)amine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

tert-butyl cinnamate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Further stages.;

DOI:10.1039/b006852g

Reference yield:

N-(4-methoxybenzyl)benzaldimine (31490-38-7) → tert-Butyl 3-[N-benzyl-N-(4-methoxybenzyl)amino]-3-phenylpropanoate (265669-70-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 10.8 g / NaBH₄ / ethanol / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 96 percent / tetrahydrofuran; hexane / 2 h / -78 °C

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; ethanol; hexane;

DOI:10.1039/b006852g

Reference yield:

benzaldehyde (100-52-7) → tert-Butyl 3-[N-benzyl-N-(4-methoxybenzyl)amino]-3-phenylpropanoate (265669-70-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / Heating

2.1: 10.8 g / NaBH₄ / ethanol / 0 - 20 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 96 percent / tetrahydrofuran; hexane / 2 h / -78 °C

With sodium tetrahydroborate; n-butyllithium; In tetrahydrofuran; ethanol; hexane;

DOI:10.1039/b006852g

upstream raw materials:

tert-butyl cinnamate

benzyl-(4-methoxybenzyl)amine

N-(4-methoxybenzyl)benzaldimine

benzaldehyde

Downstream raw materials:

tert-Butyl 3-(N-benzylamino)-3-phenylpropanoate