14429-02-8

Basic information

• Product Name: benzyl[(4-methoxyphenyl)methyl]amine
• Synonyms: benzyl[(4-methoxyphenyl)methyl]amine;OTAVA-BB 1374190;N-Benzyl-1-(4-Methoxyphenyl)MethanaMine;N-[(4-methoxyphenyl)methyl]-1-phenylmethanamine
• CAS NO: 14429-02-8
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.305
• Mol File: 14429-02-8.mol
• Article Data: 89

Chemical Properties

• Melting Point: 56 °C(Solv: methanol (67-56-1))
• Boiling Point: 170-172 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.053±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9.15±0.20(Predicted)
• CAS DataBase Reference: benzyl[(4-methoxyphenyl)methyl]amine(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl[(4-methoxyphenyl)methyl]amine(14429-02-8)
• EPA Substance Registry System: benzyl[(4-methoxyphenyl)methyl]amine(14429-02-8)

Safety Data

• HazardClass: 8
• Hazardous Substances Data: 14429-02-8(Hazardous Substances Data)

Usage

General Description

Benzyl[(4-methoxyphenyl)methyl]amine is a chemical compound with the molecular formula C15H17NO. It is a derivative of benzylamine, which is a simple aromatic amine. This specific compound features a benzene ring with a benzyl group and a 4-methoxyphenyl group connected to a central amine group. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Benzyl[(4-methoxyphenyl)methyl]amine may also have potential applications in medicinal chemistry and drug development due to its unique structure and properties.

Upstream product

• 100-52-7 benzaldehyde 
• 2393-23-9 4-methoxy-benzylamine 
• 171414-22-5 N-Benzyl-N-(4-methoxy-benzyl)-4-nitro-benzenesulfonamide 
• 171414-18-9 N-Benzyl-N-(4-methoxy-benzyl)-2-nitro-benzenesulfonamide 
• 824-94-2 p-methoxybenzyl chloride 
• 140-11-4 Benzyl acetate 
• 100-51-6 benzyl alcohol 
• 622-72-0 N-(4-methoxylbenzylidene)benzylamine 
• 100-47-0 benzonitrile 
• 105-13-5 4-Methoxybenzyl alcohol 
• 622-79-7 benzyl azide 
• 104-94-9 4-methoxy-aniline 
• 874-90-8 4-methoxybenzonitrile 
• 100-46-9 benzylamine 

Downstream Products

• 103509-42-8 benzyl-(4-methoxy-benzyl)-(2-piperidino-ethyl)-amine 
• 1027243-08-8 (1R,2S)-2-Hydroxymethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide 
• 208344-72-3 (1S,3R)-3-Hydroxymethyl-2,2-dimethyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide 
• 208344-73-4 (1R,2S,3R)-2-Hydroxymethyl-3-methyl-cyclopropanecarboxylic acid benzyl-(4-methoxy-benzyl)-amide 
• 1010438-19-3 N-benzyl-N-octyl-4-methoxybenzylamine 
• 1010438-23-9 N-benzyl-N-(3-methylbutyl)-4-methoxybenzylamine 
• 1010438-25-1 N-benzyl-N-(4-methylpentyl)-4-methoxybenzylamine 
• 1010438-27-3 N-benzyl-N-(3,3-dimethylbutyl)-4-methoxybenzylamine 
• 434906-31-7 N-benzyl-N-(4-methoxybenzyl)-3-phenylpropylamine 
• 1010438-30-8 N-benzyl-N-(4-methoxybenzyl)-4-phenylbutylamine 
• 1010438-21-7 N-benzyl-N-hexyl-4-methoxybenzylamine 
• 1027101-47-8 trans-3-(benzyl-4-methoxybenzylcarbamoyl)propenoic acid ethyl ester 
• 1119833-24-7 N-benzyl-4-cyano-N-(4-methoxybenzyl)benzenesulfonamide 
• 1119830-27-1 4-(benzyl(4-methoxybenzyl)carbamoyl)benzoic acid 

Relevant articles and documents

Application of odorless thiols for the cleavage of 2- and 4-nitrobenzenesulfonamides

Several odorless or faint-smelling thiols were tested to cleave 2- and 4-nitrobenzenesulfonyl groups, which are widely utilized for selective protection and activation of amines. p-Mercaptobenzoic acid (7) was found to be the most useful thiol for cleavin

Reductive Alkylation of Azides and Nitroarenes with Alcohols: A Selective Route to Mono- And Dialkylated Amines

Herein, we demonstrated an efficient protocol for reductive alkylation of azides/nitro compounds via a borrowing hydrogen (BH) method. By following this protocol, selective mono- and dialkylated amines were obtained under mild and solvent-free conditions. A series of control experiments and deuterium-labeling experiments were performed to understand this catalytic process. Mechanistic studies suggested that the Ir(III)-H was the active intermediate in this reaction. KIE study revealed that the breaking of the C-H bond of alcohol might be the rate-limiting step. Notably, this solvent-free strategy disclosed a high TON of around 5600. Based on kinetic studies and control experiments, a metal-ligand cooperative mechanism was proposed.

Synthesis, characterization, and antibacterial activity of dibenzildithiocarbamate derivates and Ni(II)–Cu(II) coordination compounds

In this work, the study of the synthesis methodology to obtain dibenzylamine derivates as intermediates for the formation of dithicarbamate ligands (DTC) and its coordination compounds was conducted. Four molecules derived from dibenzylamine were synthesized by two methodologies: classical (reflux) and microwave. From these amines, Four dithiocarbamate ligands (DTC): dibenzyldithiocarbamate, N-benzyl-1-(4-methoxyphenyl)dithiocarbamate, N-benzyl-1-(4-chlorophenyl)dithiocarbamate, and N-benzyl-1-(3-nitrophenyl)dithiocarbamate, and eight coordination complexes with general formula [M(DTC)2]nH2O (M= Cu(II) and Ni(II)) were obtained. All the compounds were characterized using different spectroscopic and thermal techniques such as Fourier-transform infrared spectroscopy (FT-IR), ultraviolet–visible spectroscopy (UV–VIS), proton and carbon-13 nuclear magnetic resonance (1H and 13C NMR), thermogravimetric analysis–differential scanning calorimetry (TGA-DSC). Additionally, it was possible to characterize two new crystalline phases of salts through single-crystal X-ray diffraction: dibenzyl ammonium nitrate and N-benzyl-1-(3-nitrophenyl)ammonium chloride. Additionally, microbial inhibition tests were conducted using the dibenzildithiocarbamate derivates. All DTC compounds showed important activity against Pseudomonas aeruginosa and Staphylococcus aureus but less sensitivity against Escherichia coli and Mycobacterium smegmatis. Among the coordination compounds, only [Cu(N-benzyl-1-(3-nitrophenyl)dithiocarbamate)2] presented a moderate activity against M. smegmatis mc2 155.