2-(trimethylsilyl)-6-(2-(trimethylsilyl)ethynyl)phenyl diethylcarbamate

Base Information

Chemical Name:2-(trimethylsilyl)-6-(2-(trimethylsilyl)ethynyl)phenyl diethylcarbamate
CAS No.:741695-48-7
Molecular Formula:C₁₉H₃₁NO₂Si₂
Molecular Weight:361.632
Hs Code.:

Synonyms:2-(trimethylsilyl)-6-(2-(trimethylsilyl)ethynyl)phenyl diethylcarbamate

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Chemical Property of 2-(trimethylsilyl)-6-(2-(trimethylsilyl)ethynyl)phenyl diethylcarbamate

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Technology Process of 2-(trimethylsilyl)-6-(2-(trimethylsilyl)ethynyl)phenyl diethylcarbamate

There total 5 articles about 2-(trimethylsilyl)-6-(2-(trimethylsilyl)ethynyl)phenyl diethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 75-77-4
chloro-trimethyl-silane

: 211449-24-0
diethylcarbamic acid 2-acetylphenyl ester

: 741695-48-7
2-(trimethylsilyl)-6-(2-(trimethylsilyl)ethynyl)phenyl diethylcarbamate

Guidance literature:: diethylcarbamic acid 2-acetylphenyl ester; With n-butyllithium; diethyl chlorophosphate; diisopropylamine; In tetrahydrofuran; at -78 - 0 ℃; for 3h;

chloro-trimethyl-silane; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 - 0 ℃; for 6h;
DOI:10.1021/ol049740t

Reference yield: 81.0%

: 1066-54-2
trimethylsilylacetylene

: 741695-50-1
2-iodo-6-(trimethylsilyl)phenyl diethylcarbamate

: 741695-48-7
2-(trimethylsilyl)-6-(2-(trimethylsilyl)ethynyl)phenyl diethylcarbamate

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetonitrile; at 20 ℃; for 6h;
DOI:10.1021/ol049740t

Reference yield:

: 65009-00-9
O-phenyl N,N-diethylcarbamate

: 741695-48-7
2-(trimethylsilyl)-6-(2-(trimethylsilyl)ethynyl)phenyl diethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: TMEDA; s-BuLi / tetrahydrofuran / 1 h / -78 - -30 °C

1.2: 77 percent / s-BuLi; I₂ / tetrahydrofuran / 3 h / -85 - 0 °C

2.1: 81 percent / Et₃N; CuI / Pd(PPh₃)2Cl₂ / acetonitrile / 6 h / 20 °C

With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; acetonitrile; 2.1: Sonogashira coupling;
DOI:10.1021/ol049740t