5-bromo-2-[1-(4-fluorophenyl)ethyl]-3,4-dihydroisoquinolin-1(2H)-one

Base Information

• Chemical Name: 5-bromo-2-[1-(4-fluorophenyl)ethyl]-3,4-dihydroisoquinolin-1(2H)-one
• CAS No.: 1109230-26-3
• Molecular Formula: C₁₇H₁₅BrFNO
• Molecular Weight: 348.215
• Mol file: 1109230-26-3.mol

Synonyms:5-bromo-2-[1-(4-fluorophenyl)ethyl]-3,4-dihydroisoquinolin-1(2H)-one

Chemical Property of 5-bromo-2-[1-(4-fluorophenyl)ethyl]-3,4-dihydroisoquinolin-1(2H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-2-[1-(4-fluorophenyl)ethyl]-3,4-dihydroisoquinolin-1(2H)-one

There total 4 articles about 5-bromo-2-[1-(4-fluorophenyl)ethyl]-3,4-dihydroisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-1,2,3,4-tetrahydroisoquinolin-1-one (1109230-25-2) + 1-(4-fluorophenyl)ethyl bromide (65130-46-3) → 5-bromo-2-[1-(4-fluorophenyl)ethyl]-3,4-dihydroisoquinolin-1(2H)-one (1109230-26-3)

Guidance literature:

5-bromo-1,2,3,4-tetrahydroisoquinolin-1-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Inert atmosphere;

1-(4-fluorophenyl)ethyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

1-(4-Fluorophenyl)ethanol (403-41-8) → 5-bromo-2-[1-(4-fluorophenyl)ethyl]-3,4-dihydroisoquinolin-1(2H)-one (1109230-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trimethylsilyl bromide / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

2.2: 20 h / 20 °C

With trimethylsilyl bromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2-(2-bromophenyl)ethanamine (65185-58-2) → 5-bromo-2-[1-(4-fluorophenyl)ethyl]-3,4-dihydroisoquinolin-1(2H)-one (1109230-26-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 10 °C / Reflux; Inert atmosphere

2.1: phosphoric acid / 150 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere

3.2: 20 h / 20 °C

With phosphoric acid; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

5-bromo-1,2,3,4-tetrahydroisoquinolin-1-one

1-(4-fluorophenyl)ethyl bromide

1-(4-Fluorophenyl)ethanol

methyl 2-(2-bromophenyl)ethylcarbamate

Downstream raw materials:

2-[1-(4-fluorophenyl)ethyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxylic acid

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-[1-(4-fluorophenyl)ethyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-2-[1-(4-fluorophenyl)ethyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide