N-(aminosulfonyl)-8-cyclohexyl-1a-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Chemical Name:N-(aminosulfonyl)-8-cyclohexyl-1a-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide
CAS No.:1059609-10-7
Molecular Formula:C₃₃H₃₉N₅O₅S
Molecular Weight:617.769
Hs Code.:

N-(aminosulfonyl)-8-cyclohexyl-1a-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Synonyms:N-(aminosulfonyl)-8-cyclohexyl-1a-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Chemical Property of N-(aminosulfonyl)-8-cyclohexyl-1a-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

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Technology Process of N-(aminosulfonyl)-8-cyclohexyl-1a-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

There total 11 articles about N-(aminosulfonyl)-8-cyclohexyl-1a-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1059609-09-4
N-(aminosulfonyl)-1a-((5-benzylhexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)carbonyl)-8-cyclohexyl-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

: 1059609-10-7
N-(aminosulfonyl)-8-cyclohexyl-1a-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane; for 7h; under 2585.81 Torr;

Reference yield:

: 494799-19-8
methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate

: 1059609-10-7
N-(aminosulfonyl)-8-cyclohexyl-1a-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: lithium hydroxide; water / tetrahydrofuran; methanol / 2 - 3 h / 90 °C / Heating / reflux

1.2: 1 h / 2 - 20 °C

2.1: silver carbonate / tetrahydrofuran; dichloromethane / 0 - 20 °C / Molecular sieve

3.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 0.25 h

3.2: 4 h / 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 65 °C

5.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

6.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 60 °C

6.2: 0.17 h / 20 °C

6.3: 3 h / 20 °C

7.1: sodium hydride / dimethyl sulfoxide / 0.5 h

7.2: 1 h

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

8.2: 20 °C

9.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

10.1: hydrogen / palladium 10% on activated carbon / methanol; dichloromethane / 7 h / 2585.81 Torr

With lithium hydroxide; sodium hydroxide; water; hydrogen; sodium hydride; sodium carbonate; caesium carbonate; triethylamine; HATU; 1,1'-carbonyldiimidazole; silver carbonate; trifluoroacetic acid; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 928844-30-8
13-cyclohexyl-3-methoxy-7H-indolo[2,1-a][2]benzazepine-6,10-dicarboxylic acid 10-(1,1-dimethylethyl) ester 6-methyl ester

: 1059609-10-7
N-(aminosulfonyl)-8-cyclohexyl-1a-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-ylcarbonyl)-11-methoxy-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 60 °C

2.2: 0.17 h / 20 °C

2.3: 3 h / 20 °C

3.1: sodium hydride / dimethyl sulfoxide / 0.5 h

3.2: 1 h

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

4.2: 20 °C

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol; dichloromethane / 7 h / 2585.81 Torr

With sodium hydroxide; water; hydrogen; sodium hydride; triethylamine; HATU; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;