2-fluoro-1-{N-(t-butoxycarbonyl)piperidinyl-4-oxy}-4-(benzyloxycarbonylamino)benzene

Base Information

Chemical Name:2-fluoro-1-{N-(t-butoxycarbonyl)piperidinyl-4-oxy}-4-(benzyloxycarbonylamino)benzene
CAS No.:250372-19-1
Molecular Formula:C₂₄H₂₉FN₂O₅
Molecular Weight:444.503
Hs Code.:

Synonyms:2-fluoro-1-{N-(t-butoxycarbonyl)piperidinyl-4-oxy}-4-(benzyloxycarbonylamino)benzene

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Chemical Property of 2-fluoro-1-{N-(t-butoxycarbonyl)piperidinyl-4-oxy}-4-(benzyloxycarbonylamino)benzene

Chemical Property:

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Technology Process of 2-fluoro-1-{N-(t-butoxycarbonyl)piperidinyl-4-oxy}-4-(benzyloxycarbonylamino)benzene

There total 4 articles about 2-fluoro-1-{N-(t-butoxycarbonyl)piperidinyl-4-oxy}-4-(benzyloxycarbonylamino)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 250372-19-1
2-fluoro-1-{N-(t-butoxycarbonyl)piperidinyl-4-oxy}-4-(benzyloxycarbonylamino)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / KOtBu / tetrahydrofuran / 0 - 20 °C

2: ammonium formate / 10 percent Pd/C / methanol / 2 h / Heating

3: 2.06 g / NaHCO₃ / acetone; H₂O / 6 h / 20 °C

With potassium tert-butylate; ammonium formate; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; acetone;
DOI:10.1016/S0968-0896(02)00065-2

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 250372-19-1
2-fluoro-1-{N-(t-butoxycarbonyl)piperidinyl-4-oxy}-4-(benzyloxycarbonylamino)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / KOtBu / tetrahydrofuran / 0 - 20 °C

2: ammonium formate / 10 percent Pd/C / methanol / 2 h / Heating

3: 2.06 g / NaHCO₃ / acetone; H₂O / 6 h / 20 °C

With potassium tert-butylate; ammonium formate; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; acetone;
DOI:10.1016/S0968-0896(02)00065-2

Reference yield:

: 250371-88-1
1-[N-(t-butoxycarbonyl)piperidinyl-4-oxy]-2-fluoro-4-nitrobenzene

: 250372-19-1
2-fluoro-1-{N-(t-butoxycarbonyl)piperidinyl-4-oxy}-4-(benzyloxycarbonylamino)benzene

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium formate / 10 percent Pd/C / methanol / 2 h / Heating

2: 2.06 g / NaHCO₃ / acetone; H₂O / 6 h / 20 °C

With ammonium formate; sodium hydrogencarbonate; palladium on activated charcoal; In methanol; water; acetone;
DOI:10.1016/S0968-0896(02)00065-2