3-(Methoxycarbonyl)benzophenone

Base Information

• Chemical Name: 3-(Methoxycarbonyl)benzophenone
• CAS No.: 21204-86-4
• Molecular Formula: C15H12 O3
• Molecular Weight: 240.258
• Hs Code.: 2918300090
• Mol file: 21204-86-4.mol

Synonyms:Benzoicacid, m-benzoyl-, methyl ester (8CI); 3-(Methoxycarbonyl)benzophenone;3-Benzoylbenzoic acid methyl ester; Methyl 3-benzoylbenzoate; Methylm-benzoylbenzoate; NSC 409447

Chemical Property of 3-(Methoxycarbonyl)benzophenone

Chemical Property:

• Vapor Pressure: 3.76E-06mmHg at 25°C
• Boiling Point: 385.6°C at 760 mmHg
• Flash Point: 171.6°C
• PSA: 43.37000
• Density: 1.169g/cm³
• LogP: 2.70420

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Methoxycarbonyl)benzophenone

There total 12 articles about 3-(Methoxycarbonyl)benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Trimethyl orthoacetate (1445-45-0) + 3-benzoylbenzoic acid (579-18-0) → m-benzoylbenzoic acid methyl ester (21204-86-4)

Guidance literature:

microwave irradiation;

DOI:10.1081/SCC-120005431

Reference yield: 90.0%

methanol (67-56-1) + 3-benzoylbenzoic acid (579-18-0) → m-benzoylbenzoic acid methyl ester (21204-86-4)

Guidance literature:

With toluene-4-sulfonic acid; at 75 ℃; for 18h;

Reference yield: 85.0%

carbon monoxide (201230-82-2) + methyl 3-iodo-benzoate (618-91-7) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → m-benzoylbenzoic acid methyl ester (21204-86-4)

Guidance literature:

With bis(η3-allyl-μ-chloropalladium(II)); silver trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 100 ℃; for 24h; under 3040.2 Torr; Inert atmosphere; Sealed tube; Glovebox; Schlenk technique; Green chemistry;

DOI:10.1038/NCHEM.2903

upstream raw materials:

diazomethane

3-benzoylbenzoic acid

methanol

methyl iodide

Downstream raw materials:

3-benzyl-benzoic acid methyl ester

3-[(2-Benzenesulfonylamino-ethylsulfanyl)-phenyl-methyl]-benzoic acid methyl ester

3-[(2-Benzenesulfonylamino-ethylsulfanyl)-phenyl-methyl]-benzoic acid

3-[(2-Amino-ethylsulfanyl)-phenyl-methyl]-benzoic acid methyl ester

Refernces

• 1、 Kinney, R. Garrison,Tjutrins, Jevgenijs,Torres, Gerardo M.,Liu, Nina Jiabao,Kulkarni, Omkar,Arndtsen, Bruce A.. "A general approach to intermolecular carbonylation of arene C-H bonds to ketones through catalytic aroyl triflate formation". . p. 193 - 199. Retrieved 2018/02/06.
• 2、 -. "COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY". Page/Page column 135. . Retrieved 2013/02/27.