ethyl 4-(4-(trifluoromethyl)phenyl)-3-oxobutanoate

Base Information

• Chemical Name: ethyl 4-(4-(trifluoromethyl)phenyl)-3-oxobutanoate
• CAS No.: 1048916-79-5
• Molecular Formula: C₁₃H₁₃F₃O₃
• Molecular Weight: 274.24
• Mol file: 1048916-79-5.mol

Synonyms:ethyl 3-oxo-4-(4-(trifluoromethyl)phenyl)butanoate

Chemical Property of ethyl 4-(4-(trifluoromethyl)phenyl)-3-oxobutanoate

Chemical Property:

Purity/Quality:

ethyl4-(4-(trifluoromethyl)phenyl)-3-oxobutanoate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(4-(trifluoromethyl)phenyl)-3-oxobutanoate

There total 5 articles about ethyl 4-(4-(trifluoromethyl)phenyl)-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cycl-isopropylidene malonate (2033-24-1) + ethanol (64-17-5) + 4-(trifluoromethyl)phenylacetyl chloride (74426-51-0) → ethyl 3-oxo-4-(4-(trifluoromethyl)phenyl)butanoate (1048916-79-5)

Guidance literature:

cycl-isopropylidene malonate; ethanol; 4-(trifluoromethyl)phenylacetyl chloride; With pyridine; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;

In ethanol; dichloromethane; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.113497

Reference yield:

4-Trifluoromethylphenylacetic acid (32857-62-8) + magnesium bis(3-ethoxy-3-oxopropanoate) (37517-78-5) → ethyl 3-oxo-4-(4-(trifluoromethyl)phenyl)butanoate (1048916-79-5)

Guidance literature:

4-Trifluoromethylphenylacetic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

magnesium bis(3-ethoxy-3-oxopropanoate); In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm900212y

Reference yield:

ethanol (64-17-5) + C15H13F3O5 (1621689-62-0) → ethyl 3-oxo-4-(4-(trifluoromethyl)phenyl)butanoate (1048916-79-5)

Guidance literature:

Reflux;

DOI:10.1016/j.ejmech.2014.07.033

upstream raw materials:

4-Trifluoromethylphenylacetic acid

magnesium bis(3-ethoxy-3-oxopropanoate)

4-(trifluoromethyl)phenylacetyl chloride

ethanol

Downstream raw materials:

ethyl (2Z)-3-amino-4-(4-trifluoromethylphenyl)but-2-enoate

Refernces

• 1、 Wang, Hsiao-Chun,Jagtap, Ajit Dhananjay,Chang, Pei-Teh,Liu, Jia-Rong,Liu, Chih-Peng,Tseng, Hsiang-Wen,Chen, Grace Shiahuy,Chern, Ji-Wang. "Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor". . p. 312 - 334. Retrieved 2014/08/05.