N-(1-cyano-2-phenylethyl)-3-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>propanamide

Base Information

Chemical Name:N-(1-cyano-2-phenylethyl)-3-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>propanamide
CAS No.:127086-77-5
Molecular Formula:C₂₉H₃₀N₂O₄
Molecular Weight:470.568
Hs Code.:

Synonyms:N-(1-cyano-2-phenylethyl)-3-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>propanamide

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Chemical Property of N-(1-cyano-2-phenylethyl)-3-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>propanamide

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Technology Process of N-(1-cyano-2-phenylethyl)-3-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>propanamide

There total 7 articles about N-(1-cyano-2-phenylethyl)-3-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 156-38-7
4-hydroxyphenylacetate

: 127086-77-5
N-(1-cyano-2-phenylethyl)-3-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>propanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / conc. H₂SO₄ / Heating

2: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT

3: 98 percent / H₂, / 10percent Pd/C / ethyl acetate / 3 h

4: 99.8 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

5: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl₃, 0 deg C, 15 min, 2.) 0 deg C to RT

With 18-crown-6 ether; sulfuric acid; hydrogen; potassium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039

Reference yield:

: 41997-33-5
iso-propyl 4-hydroxyphenylacetate

: 127086-77-5
N-(1-cyano-2-phenylethyl)-3-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT

2: 98 percent / H₂, / 10percent Pd/C / ethyl acetate / 3 h

3: 99.8 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

4: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl₃, 0 deg C, 15 min, 2.) 0 deg C to RT

With 18-crown-6 ether; hydrogen; potassium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039

Reference yield:

: 93139-50-5
3-phenylpropionic acid tert-butyl ester

: 127086-77-5
N-(1-cyano-2-phenylethyl)-3-phenyl-3-<4-<(isopropoxycarbonyl)methyl>phenoxy>propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT

2: 98 percent / H₂, / 10percent Pd/C / ethyl acetate / 3 h

3: 99.8 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / 0 °C

4: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl₃, 0 deg C, 15 min, 2.) 0 deg C to RT

With 18-crown-6 ether; hydrogen; potassium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039