1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone

Base Information

Chemical Name:1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone
CAS No.:1314012-51-5
Molecular Formula:C₁₈H₁₂F₃NO₂
Molecular Weight:331.294
Hs Code.:

Synonyms:1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone

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Chemical Property of 1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone

Chemical Property:

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Technology Process of 1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone

There total 2 articles about 1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 158580-95-1
6,7-difluoro-1H-indole-2,3-dione

: 1314012-51-5
1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / water / cooling with ice

1.2: 20 - 25 °C

2.1: nitrobenzene / 1 h / 130 - 150 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

With potassium carbonate; potassium hydroxide; In water; nitrobenzene; N,N-dimethyl-formamide;

Reference yield:

: 4519-40-8
2,3-difluoroanilline

: 1314012-51-5
1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium sulfate / water / 10 h / 50 °C

1.2: 0.5 h / 20 °C

1.3: 1 h / 80 - 90 °C

2.1: potassium hydroxide / water / cooling with ice

2.2: 20 - 25 °C

3.1: nitrobenzene / 1 h / 130 - 150 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

With hydroxylamine hydrochloride; potassium carbonate; sodium sulfate; potassium hydroxide; In water; nitrobenzene; N,N-dimethyl-formamide;

Reference yield:

: 1314012-51-5
1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone

: 676-58-4
methylmagnesium chloride

: 1314008-27-9
(2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol)

Guidance literature:: 1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone; methylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;