(2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol)

Base Information

Chemical Name:(2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol)
CAS No.:1314008-27-9
Molecular Formula:C₁₉H₁₆F₃NO₂
Molecular Weight:347.337
Hs Code.:

Synonyms:(2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol)

Suppliers and Price of (2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of (2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol)

Chemical Property:

Purity/Quality:: 98%+ ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol)

There total 4 articles about (2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314012-51-5
1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone

: 676-58-4
methylmagnesium chloride

: 1314008-27-9
(2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol)

Guidance literature:: 1-[2-fluoro-6-(7,8-difluoro-2-methylquinolin-3-yloxy)-phenyl]-ethanone; methylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 158580-95-1
6,7-difluoro-1H-indole-2,3-dione

: 1314008-27-9
(2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol)

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / water / cooling with ice

1.2: 20 - 25 °C

2.1: nitrobenzene / 1 h / 130 - 150 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

4.1: tetrahydrofuran / 2 h / 0 - 20 °C

With potassium carbonate; potassium hydroxide; In tetrahydrofuran; water; nitrobenzene; N,N-dimethyl-formamide;

Reference yield:

: 4519-40-8
2,3-difluoroanilline

: 1314008-27-9
(2-{2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl}propan-2-ol)

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; sodium sulfate / water / 10 h / 50 °C

1.2: 0.5 h / 20 °C

1.3: 1 h / 80 - 90 °C

2.1: potassium hydroxide / water / cooling with ice

2.2: 20 - 25 °C

3.1: nitrobenzene / 1 h / 130 - 150 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

5.1: tetrahydrofuran / 2 h / 0 - 20 °C

With hydroxylamine hydrochloride; potassium carbonate; sodium sulfate; potassium hydroxide; In tetrahydrofuran; water; nitrobenzene; N,N-dimethyl-formamide;