N-(2-(2-(2-(2-(3-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethylamino)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

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Chemical Name:N-(2-(2-(2-(2-(3-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethylamino)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
CAS No.:1426406-59-8
Molecular Formula:C₄₃H₆₀FN₇O₇S
Molecular Weight:838.057
Hs Code.:

N-(2-(2-(2-(2-(3-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethylamino)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Synonyms:N-(2-(2-(2-(2-(3-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethylamino)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

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Chemical Property of N-(2-(2-(2-(2-(3-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethylamino)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

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Technology Process of N-(2-(2-(2-(2-(3-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethylamino)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

There total 10 articles about N-(2-(2-(2-(2-(3-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethylamino)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethanamine

: 365441-71-0
4,7,10,13-tetraoxa-16-azaheneicosanoic acid 21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-2,5-dioxo-1-pyrrolidinyl ester

: 1426406-59-8
N-(2-(2-(2-(2-(3-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethylamino)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2013.01.010

Reference yield:

: 188343-76-2
benzyl 4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidine-1-carboxylate

: 1426406-59-8
N-(2-(2-(2-(2-(3-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethylamino)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; hydrogenchloride

2: triethylamine / acetonitrile / 60 °C

3: trifluoroacetic acid / 6.5 h / 20 °C

4: triethylamine / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bmcl.2013.01.010

Reference yield:

: 85475-10-1
4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester

: 1426406-59-8
N-(2-(2-(2-(2-(3-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethylamino)-3-oxopropoxy)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; dimethyl sulfoxide / 0.58 h / Inert atmosphere

1.2: 2 h / Inert atmosphere

2.1: ammonium acetate; acetic acid / 110 °C

3.1: acetic acid; hydrogenchloride

4.1: triethylamine / acetonitrile / 60 °C

5.1: trifluoroacetic acid / 6.5 h / 20 °C

6.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

With hydrogenchloride; ammonium acetate; acetic acid; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.bmcl.2013.01.010