(Z)-2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLIC ACID

Base Information

• Chemical Name: (Z)-2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLIC ACID
• CAS No.: 88681-63-4
• Molecular Formula: C11H10 Cl N O3
• Molecular Weight: 239.658
• Hs Code.: 2924299090
• Mol file: 88681-63-4.mol

Synonyms:2-Propenoicacid, 2-(acetylamino)-3-(4-chlorophenyl)-, (Z)-;(2Z)-2-(Acetylamino)-3-(4-chlorophenyl)-2-propenoic acid

Chemical Property of (Z)-2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLIC ACID

Chemical Property:

• PSA: 69.89000
• LogP: 2.74190

Purity/Quality:

99% ^*data from raw suppliers

(2Z)-2-(Acetylamino)-3-(4-chlorophenyl)acrylicacid 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLIC ACID

There total 14 articles about (Z)-2-ACETAMIDO-3-(4-CHLOROPHENYL)ACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-chlorobenzaldehyde (104-88-1) + N-acetylglycine (543-24-8) → 2-acetamido-3-(4-chlorophenyl)acrylic acid (88681-63-4,3617-00-3)

Guidance literature:

With sodium acetate; In acetic anhydride; for 4h; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2014.03.034

Reference yield: 86.0%

(Z)-4-(4-chlorobenzylidene)-2-methyloxazol-5(4H)-one (93634-55-0) → (Z)-2-acetamido-3-(4-chlorophenyl)acrylic acid (88681-63-4)

Guidance literature:

With water; In acetone; for 6h; Heating;

DOI:10.1080/07328319308018563

Reference yield: 81.1%

2-methyl-4-(4-chlorobenzylidene)-4H-oxazol-5-one (93634-55-0,3237-71-6) → 2-acetamido-3-(4-chlorophenyl)acrylic acid (88681-63-4,3617-00-3)

Guidance literature:

With hydrogenchloride; water; In acetone; for 3h; Heating / reflux;

upstream raw materials:

2-methyl-4-(4-chlorobenzylidene)-4H-oxazol-5-one

4-chlorobenzaldehyde

N-acetylglycine

bromochlorobenzene

Downstream raw materials:

β-(4-chlorophenyl)pyruvic acid

6-(p-chlorobenzyl)-4-amino-3-mercapto-1,2,4-triazin-5-one

6-(4-Chloro-benzyl)-3-mercapto-4-{[1-p-tolyl-meth-(E)-ylidene]-amino}-4H-[1,2,4]triazin-5-one

6-(4-Chloro-benzyl)-3-mercapto-4-{[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amino}-4H-[1,2,4]triazin-5-one