4,6,8-TRIMETHYLQUINOLINE

Base Information

• Chemical Name: 4,6,8-TRIMETHYLQUINOLINE
• CAS No.: 88565-88-2
• Molecular Formula: C12H13 N
• Molecular Weight: 171.24
• Hs Code.: 2933499090
• Mol file: 88565-88-2.mol

Synonyms:4,6,8-Trimethylquinoline

Chemical Property of 4,6,8-TRIMETHYLQUINOLINE

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Melting Point: 57°C
• Refractive Index: 1.6
• Boiling Point: 294.755ºC at 760 mmHg
• Flash Point: 123.487ºC
• PSA: 12.89000
• Density: 1.034g/cm3
• LogP: 3.16000

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,6,8-Trimethylquinoline >98.0%(GC)(T) ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6,8-TRIMETHYLQUINOLINE

There total 8 articles about 4,6,8-TRIMETHYLQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

methyl vinyl ketone (78-94-4,25038-87-3) + 2,4-Xylidine (95-68-1) → 4,6,8-trimethylquinoline (88565-88-2)

Guidance literature:

2,4-Xylidine; With anhydrous zinc chloride; In ethanol; water monomer; at 40 ℃; for 0.5h;

With ferric(III) chloride; In ethanol; water monomer; at 80 ℃; for 1h;

methyl vinyl ketone; In ethanol; water monomer; at 80 ℃; for 15h;

DOI:10.1021/acs.joc.1c03007

Reference yield:

2-chloro-4,6,8-trimethyl-quinoline (139719-24-7) → 4,6,8-trimethylquinoline (88565-88-2)

Guidance literature:

With palladium on activated charcoal; sodium acetate; acetic acid; Hydrogenation;

DOI:10.1021/ja01208a035

Reference yield:

4,6,8-trimethyl-quinolin-2-ol (42414-28-8) → 4,6,8-trimethylquinoline (88565-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: phosphoryl chloride

2: palladium/charcoal; sodium acetate; acetic acid / Hydrogenation

With palladium on activated charcoal; sodium acetate; acetic acid; trichlorophosphate;

DOI:10.1021/ja01208a035

upstream raw materials:

2-chloro-4,6,8-trimethyl-quinoline

2,4-xylidine hydrochloride

methyl vinyl ketone

formaldehyd

Downstream raw materials:

4-[trans-2-(6,8-dimethyl-[4]quinolyl)-vinyl]-N,N-dimethyl-aniline

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