N-(2-bromo-4-heptafluoroisopropyl-6-trifluoromethylphenyl)-2-fluoro-3 -methylaminobenzamide

Base Information

• Chemical Name: N-(2-bromo-4-heptafluoroisopropyl-6-trifluoromethylphenyl)-2-fluoro-3 -methylaminobenzamide
• CAS No.: 1207315-58-9
• Molecular Formula: C₁₈H₁₀BrF₁₁N₂O
• Molecular Weight: 559.177
• Mol file: 1207315-58-9.mol

Synonyms:N-(2-bromo-4-heptafluoroisopropyl-6-trifluoromethylphenyl)-2-fluoro-3 -methylaminobenzamide

Chemical Property of N-(2-bromo-4-heptafluoroisopropyl-6-trifluoromethylphenyl)-2-fluoro-3 -methylaminobenzamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromo-4-heptafluoroisopropyl-6-trifluoromethylphenyl)-2-fluoro-3 -methylaminobenzamide

There total 10 articles about N-(2-bromo-4-heptafluoroisopropyl-6-trifluoromethylphenyl)-2-fluoro-3 -methylaminobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-amino-N-[2-bromo-4-[1,1,1,2,3,3,3-heptafluoroprop-2-yl]-6-(trifluoromethyl)phenyl]-2-fluorobenzamide (1207314-89-3) → N-(2-bromo-4-heptafluoroisopropyl-6-trifluoromethylphenyl)-2-fluoro-3 -methylaminobenzamide (1207315-58-9)

Guidance literature:

With sulfuric acid; In water; at 30 - 40 ℃;

Reference yield:

N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)phenyl]-3-nitro-2-fluorobenzamide (1207314-88-2) → N-(2-bromo-4-heptafluoroisopropyl-6-trifluoromethylphenyl)-2-fluoro-3 -methylaminobenzamide (1207315-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; tin(ll) chloride / ethanol; water / 4 h / 60 °C

1.2: pH 10

2.1: sulfuric acid / water / 40 °C

2.2: pH 10

With hydrogenchloride; sulfuric acid; tin(ll) chloride; In ethanol; water;

Reference yield:

N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-2-chloro-3-nitrobenzamide (1207314-87-1) → N-(2-bromo-4-heptafluoroisopropyl-6-trifluoromethylphenyl)-2-fluoro-3 -methylaminobenzamide (1207315-58-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium fluoride / N,N-dimethyl-formamide / 10 h / 130 °C / Inert atmosphere

2.1: hydrogenchloride; tin(ll) chloride / ethanol; water / 4 h / 60 °C

2.2: pH 10

3.1: sulfuric acid / water / 40 °C

3.2: pH 10

With hydrogenchloride; potassium fluoride; sulfuric acid; tin(ll) chloride; In ethanol; water; N,N-dimethyl-formamide;

upstream raw materials:

N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-2-chloro-3-nitrobenzamide

N-[2-bromo-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-6-(trifluoromethyl)phenyl]-3-nitro-2-fluorobenzamide

formaldehyd

3-amino-N-[2-bromo-4-[1,1,1,2,3,3,3-heptafluoroprop-2-yl]-6-(trifluoromethyl)phenyl]-2-fluorobenzamide

Downstream raw materials:

3-[benzoyl(methyl)amino]-N-[2-bromo-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]-6-(trifluoromethyl)phenyl]-2-fluorobenzamide

N-(2-bromo-4-(perfluoropropan-2-yl)-6-(trifluoromethyl)phenyl)-2-fluoro-N-methyl-3-(N-methylbenzamide)benzamide