7-(benzyloxy)-2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

Base Information

Chemical Name:7-(benzyloxy)-2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine
CAS No.:1320288-41-2
Molecular Formula:C₃₀H₄₀N₄O₂
Molecular Weight:488.673
Hs Code.:

Synonyms:7-(benzyloxy)-2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

Suppliers and Price of 7-(benzyloxy)-2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(benzyloxy)-2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-(benzyloxy)-2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

There total 8 articles about 7-(benzyloxy)-2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1320288-39-8
7-(benzyloxy)-4-chloro-2-cyclohexyl-6-methoxyquinazoline

: 127285-08-9
4-amino-1-isopropylpiperidine

: 1320288-41-2
7-(benzyloxy)-2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 160 ℃; for 0.25h; Microwave irradiation;
DOI:10.1021/jm200903z

Reference yield:

: 385785-02-4
2-amino-4-(benzyloxy)-5-methoxybenzonitrile

: 1320288-41-2
7-(benzyloxy)-2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

2: dihydrogen peroxide; sodium hydroxide / ethanol; water / 2 h / Reflux

3: N,N-diethylaniline; trichlorophosphate / 4 h / Reflux

4: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation

With dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm200903z

Reference yield:

: 385784-84-9
4-(benzyloxy)-5-methoxy-2-nitrobenzonitrile

: 1320288-41-2
7-(benzyloxy)-2-cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxyquinazolin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1: water; iron; ammonium chloride / isopropyl alcohol / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

3: dihydrogen peroxide; sodium hydroxide / ethanol; water / 2 h / Reflux

4: N,N-diethylaniline; trichlorophosphate / 4 h / Reflux

5: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation

With water; dihydrogen peroxide; iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; N,N-diethylaniline; sodium hydroxide; trichlorophosphate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm200903z