octa(ethylene glycol) di[[4-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]aminocarbonyl]benzyl] ether

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Chemical Name:octa(ethylene glycol) di[[4-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]aminocarbonyl]benzyl] ether
CAS No.:1355460-51-3
Molecular Formula:C₆₂H₉₂N₆O₁₃
Molecular Weight:1129.44
Hs Code.:

Synonyms:octa(ethylene glycol) di[[4-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]aminocarbonyl]benzyl] ether

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Chemical Property of octa(ethylene glycol) di[[4-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]aminocarbonyl]benzyl] ether

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Technology Process of octa(ethylene glycol) di[[4-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]aminocarbonyl]benzyl] ether

There total 4 articles about octa(ethylene glycol) di[[4-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]aminocarbonyl]benzyl] ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1355460-32-0
4,4'-(2,5,8,11,14,17,20,23,26-nonoxaheptacosane-1,27-diyl)dibenzoic acid

: 21103-33-3
4-[4-(2-methoxyphenyl)piperazin-1-yl]butylamine

: 1355460-51-3
octa(ethylene glycol) di[[4-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]aminocarbonyl]benzyl] ether

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2011.10.063

Reference yield:

: 1355460-27-3
dimethyl 4,4'-(2,5,8,11,14,17,20,23,26-nonoxaheptacosane-1,27-diyl)dibenzoate

: 1355460-51-3
octa(ethylene glycol) di[[4-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]aminocarbonyl]benzyl] ether

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 4 h / Reflux

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.10.063

Reference yield:

: 5117-19-1
octaethylene glycol

: 1355460-51-3
octa(ethylene glycol) di[[4-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]aminocarbonyl]benzyl] ether

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0 °C

1.2: 2 h / 20 °C

2.1: sodium hydroxide / methanol; water / 4 h / Reflux

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C

With potassium hexamethylsilazane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.10.063