9-cyclohexyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

Base Information

Chemical Name:9-cyclohexyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one
CAS No.:1398113-59-1
Molecular Formula:C₁₅H₂₂N₄O₃
Molecular Weight:306.365
Hs Code.:

Synonyms:9-cyclohexyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

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Chemical Property of 9-cyclohexyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

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Technology Process of 9-cyclohexyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

There total 1 articles about 9-cyclohexyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22870-26-4
methyl 3-cyclohexylaminopropionate

: 1398113-59-1
9-cyclohexyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: tert-butyl alcohol / 8 h / Reflux

2: sodium dithionite / ethanol; water / 6 h / Reflux

With sodium dithionite; In ethanol; water; tert-butyl alcohol;
DOI:10.1016/j.tetlet.2012.06.143

Reference yield: 98.0%

: 1398113-59-1
9-cyclohexyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

: 75-26-3
isopropyl bromide

: 1398113-65-9
9-cyclohexyl-5-isopropyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

Guidance literature:: 9-cyclohexyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one; With tetrabutylammomium bromide; potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

isopropyl bromide; In acetonitrile; at 50 ℃; for 2h;
DOI:10.1016/j.tetlet.2012.06.143

Reference yield: 88.0%

: 1398113-59-1
9-cyclohexyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

: 74-88-4
methyl iodide

: 1398113-64-8
9-cyclohexyl-2,4-dimethoxy-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one

Guidance literature:: 9-cyclohexyl-2,4-dimethoxy-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.25h;

methyl iodide; In tetrahydrofuran; mineral oil;
DOI:10.1016/j.tetlet.2012.06.143