1-(4-Phenoxyphenyl)ethanol

Base Information

• Chemical Name: 1-(4-Phenoxyphenyl)ethanol
• CAS No.: 4974-85-0
• Molecular Formula: C₁₄H₁₄O₂
• Molecular Weight: 214.264
• DSSTox Substance ID: DTXSID801345871
• Nikkaji Number: J354.726D
• Mol file: 4974-85-0.mol

Synonyms:1-(4-Phenoxyphenyl)ethanol;4974-85-0;1-(4-PHENOXYPHENYL)ETHYL ALCOHOL;SCHEMBL4368301;DTXSID801345871;1-(4-PHENOXYPHENYL)ETHAN-1-OL

Chemical Property of 1-(4-Phenoxyphenyl)ethanol

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 214.099379685
• Heavy Atom Count: 16
• Complexity: 191

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Phenoxyphenyl)ethanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=CC=C(C=C1)OC2=CC=CC=C2)O

Technology Process of 1-(4-Phenoxyphenyl)ethanol

There total 18 articles about 1-(4-Phenoxyphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-phenoxyacetophenone (5031-78-7) → 1-(4-phenoxyphenyl)ethyl alcohol (4974-85-0)

Guidance literature:

With diethoxymethylane; iron(II) acetate; In tetrahydrofuran; at 65 ℃; for 24h;

DOI:10.1016/j.tetlet.2007.11.002

Reference yield: 80.0%

1-(4-Fluorophenyl)ethanol (403-41-8) + phenol (108-95-2,27073-41-2) → 1-(4-phenoxyphenyl)ethyl alcohol (4974-85-0)

Guidance literature:

1-(4-Fluorophenyl)ethanol; phenol; With carbonyl bis(hydrido)tris(triphenylphosphine)ruthenium(II); potassium carbonate; 1,2-bis-(diphenylphosphino)ethane; In dimethyl sulfoxide; acetone; at 130 ℃; for 24h; Microwave irradiation; Sealed tube;

With formic acid; In dimethyl sulfoxide; acetone; at 130 ℃; for 24h; Microwave irradiation; Sealed tube;

DOI:10.1021/acs.orglett.7b03441

Reference yield:

4-phenoxyacetophenone (5031-78-7) → 1-(4-phenoxyphenyl)ethyl alcohol (4974-85-0) + bis-[1-(4-phenoxy-phenyl)-ethyl]-ether (328271-02-9)

Guidance literature:

With aluminum isopropoxide; isopropyl alcohol; at 100 ℃;

DOI:10.1021/ja01211a082

upstream raw materials:

4-phenoxyacetophenone

p-Phenoxy-α-methylbenzylchlorid

methanol

2,2,2-trifluoroethanol

Downstream raw materials:

p-Phenoxy-α-methylbenzylchlorid

C₁₄H₁₃O⁽¹⁺⁾

4-phenoxystyrene

4-phenoxyanilin